New insights into the systemic effects of oral lactoferrin: transcriptome profiling

Kruzel, Marian L.; Olszewska, Paulina; Pazdrak, Barbara; Krupińska, A; Actor, Jeffrey K.

doi:10.1139/bcb-2020-0069

Cited by 20 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study showed improvements in COVID-19 symptoms including fever, dry cough, diarrhea, headache, loss of sense of taste and/or smell and tiredness after the seventh day of starting treatment with Lf in all groups, however these changes showed no statistically significant difference among studied groups. These findings can be explained by the established broad-spectrum antiviral, anti-inflammatory and immunomodulatory properties of Lf [ 11 , 22 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study

et al. 2021

View full text Add to dashboard Cite

Background and Objectives: Preventive, adjunctive and curative properties of lactoferrin have been evaluated since the first wave of severe acute respiratory syndrome coronavirus (SARS-CoV), a viral respiratory disease, emerged 18 years ago. Despite the discovery of new vaccine candidates, there is currently no widely approved treatment for SARS-CoV-2 (COVID-19). Strict adherence to infection prevention and control procedures, as well as vaccines, can, however, prevent the spread of SARS-CoV-2. This study aimed to evaluate the efficacy of lactoferrin treatment in improving clinical symptoms and laboratory indices among individuals with mild to moderate coronavirus disease-19 (COVID-19). Materials and Method: A randomized, prospective, interventional pilot study conducted between 8 July and 18 September 2020 used a hospital-based sample of 54 laboratory-confirmed participants with mild to moderate symptoms of COVID-19. Randomization into a control and two treatment groups ensured all groups received the approved Egyptian COVID-19 management protocol; only treatment group participants received lactoferrin at different doses for seven days. Clinical symptoms and laboratory indices were assessed on Days 0, 2 and 7 after starting treatments. Mean values with standard deviation and one-way analysis of variance with least significant difference of demographic and laboratory data between control and treatment groups were calculated. Results: Our study showed no statistically significant difference among studied groups regarding recovery of symptoms or laboratory improvement. Conclusions: Further research into therapeutic properties particularly related to dosage, duration and follow-up after treatment with lactoferrin in individuals with COVID-19 is required.

show abstract

Section: Discussionmentioning

confidence: 99%

The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Lactoferrin (LF) is the first line of defense proteins present in mammals, can treat diseases that impair immune homeostasis through immunomodulation, and has the ability to bridge innate immunity and adaptive immunity [86]. In rats, the comparison of differentially expressed genes after 6 h of LF oral and intravenous injection showed that 72.8% of gene changes after oral recombinant human LF (rhLF) administration were the same as those after the intravenous treatment.…”

Section: Oral Dietary Control Of Oxidative Stressmentioning

confidence: 99%

“…These two pathways show similarities in the upregulation of specific genes related to oxidative stress and inflammation. Therefore, LF can be supplemented through oral administration [86].…”

Section: Oral Dietary Control Of Oxidative Stressmentioning

confidence: 99%

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Jiang

Liu

2021

Foods

View full text Add to dashboard Cite

Oxidative stress is a status of imbalance between oxidants and antioxidants, resulting in molecular damage and interruption of redox signaling in an organism. Indeed, oxidative stress has been associated with many metabolic disorders due to unhealthy dietary patterns and may be alleviated by properly increasing the intake of antioxidants. Thus, it is quite important to adopt a healthy dietary mode to regulate oxidative stress and maintain cell and tissue homeostasis, preventing inflammation and chronic metabolic diseases. This review focuses on the links between dietary nutrients and health, summarizing the role of oxidative stress in ‘unhealthy’ metabolic pathway activities in individuals and how oxidative stress is further regulated by balanced diets.

show abstract

“…In this way LTF may augment the immunity of all mucous membranes (eyes, gastrointestinal, urinary and reproductive tracts and airways) protecting against penetration of pathogens and development of excessive inflammation [ 58 , 112 ]. LTF, applied orally to rats, altered expression of numerous genes, such as genes coding for IL-1β, TNF-α, TNF-β and cellular receptors CD40L, CD80, IL-5R on peripheral blood leukocytes, similarly to the effects of intravenously administered LTF [ 113 ].…”

Section: Lactoferrin As a Diet Supplementmentioning

confidence: 99%

Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review

Artym

Zimecki

Kruzel³

2021

Biomedicines

Self Cite

View full text Add to dashboard Cite

Pregnancy is a physiological state that demands higher level of nutrients, including vitamins and minerals, for the growth and maintenance of the fetus. Iron deficiency is a part of most common diet deficiencies in pregnancy and has high clinical significance leading to the development of syderopenic anemia and its consequences for mother and child, such as higher risk of perinatal death, susceptibility to infection, intra-uteral growth inhibition, prematurity and low birth weight. Hence, iron supplementation is recommended for pregnant women; however dietary intake of iron from most commercially available formulas is often insufficient due to iron-poor bioavailability, or have undesired side-effects in the gastrointestinal tract, resulting in a discouraging and distrustful attitude to such treatment. The results of numerous studies indicate that diet supplementation with lactoferrin (LTF), an iron-binding protein, may be advantageous in prophylaxis and treatment of iron deficiency anemia. LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes. LTF also protects against infections and inflammatory complications, caused by diagnostic surgical interventions in pregnant women. Beneficial, multidirectional actions of LTF during pregnancy encompass, in addition, inhibition of oxidative stress, normalization of intestine and genital tract microbiota and carbohydrate-lipid metabolism, protection of intestine barrier function, promotion of wound healing, as well as hypotensive, analgesic and antistress actions. Bovine lactoferrin (BLTF) is readily available on the nutritional market and generally recognized as safe (GRAS) for use in human diet.

show abstract

New insights into the systemic effects of oral lactoferrin: transcriptome profiling

Cited by 20 publications

References 37 publications

The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study

The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review

Contact Info

Product

Resources

About