New insights into the identification of bioactive compounds from Willughbeia edulis Roxb. through GC–MS analysis

Sami, Saad Ahmed

doi:10.1186/s43088-022-00270-8

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Samples of sea bamboo (I. hippuris) collected from Biak, Papua, have previously been evaluated for bioactive compounds by using GC-MS instrument. Gas Chromatography-Mass Spectrometry (GC-MS) is a convenient instrument to determine the quantitative amount of bioactive compounds in an organism extract (Sami, 2022). GC-MS analysis has advantages, including identifying various bioactive compounds, including organic acids, phenolic compounds, alkaloids, phytosterols, esters, and ketones (El-Naggar et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

CHARACTERIZATION OF ANTIOXIDANT COMPOUNDS FROM CELEBES SEA BAMBOO EXTRACTS (Isis hippuris) USING GC-MS

Tanod,

Dewanto,

Cahyono

et al. 2023

JPK UNTIRTA

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Sea bamboo (Isis hippuris) is one of the octocorallia classes that has unique biological activity and is beneficial for pharmaceutical development. Evaluation of bioactive compounds from sea bamboo collected from Sulawesi (Celebes) waters has been previously reported but lacks information. Gas chromatography and mass spectrometry (GC-MS) are one of the instruments used to evaluate bioactive compounds. This study aims to evaluate bioactive compounds from extracts of sea bamboo from Sulawesi by GC-MS, analyze their antioxidant properties using the DPPH method, and predict their activity computationally using PASS. Samples of sea bamboo were collected from Kabonga Besar Coast, Palu Bay, Central Sulawesi, Indonesia. Samples were extracted by maceration method using methanol: dichloromethane solvent (1:1). GC-MS evaluation identified six alkaloid-derived compounds, namely tetramethyldiaminoethane, dimethylisopropanolamine, 2,4-dimethylpyrrole, 1-(carboxymethyl)pyridinium chloride, pyridine, 3,4-dimethyl-, and N-nitroso-2-methylthiazolidine. The Celebes sea bamboo extracts have potent antioxidant activity. Tetramethyldiaminoethane and dimethylisopropanolamine compounds are predicted to have antioxidant abilities closely related to their role as NADPH-oxidase inhibitors.

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Section: Introductionmentioning

confidence: 99%

CHARACTERIZATION OF ANTIOXIDANT COMPOUNDS FROM CELEBES SEA BAMBOO EXTRACTS (Isis hippuris) USING GC-MS

Tanod,

Dewanto,

Cahyono

et al. 2023

JPK UNTIRTA

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Unveiling the Bioprospecting Efficacy and Textile Dyeing of a Novel Endophytic Mycobial Red Pigment

Mani,

Thangavel,

Surendrababu

et al. 2024

Indian J Microbiol

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Natural pigments are getting prominence because of the hazardous effects from the use of synthetic colouring chemicals. Microbial pigments, in addition to their vast biological activities, provide an easily accessible alternative supply of natural colours. A total of twenty-four fungal cultures were isolated from the leaf tissues of Senna auriculata, out of which a distinctive strain (FNG1) exhibited an extracellular pigmentation of reddish orange. The isolate was identi ed as Nigrospora oryzae based on morphological traits and a molecular phylogenetic study of a combined Internal Transcribed Spacer (ITS) and β-tubulin analysis. The crude red pigment was the most soluble in ethyl acetate. The natural pigment was characterised and partly puri ed using thin-layer chromatography. As a result, the partly puri ed fungal pigment Ergo, was used in further bioprospecting investigations. The antimicrobial activity of the partly puri ed sample was evaluated against eight human pathogens, with the maximum zone of inhibition identi ed in Leucobacter AA7 (200-500 µg/mL). DPPH scavenging activity of the compound increased from 38.2-67.9% with an IC 50 value of 34.195 ± 2.33 µg/mL. The cytotoxicity of partially puri ed fungal pigment inhibited cancer cells while having little effect on non-cancerous HEK293 T cells. The gas chromatography-mass spectrometry (GC-MS) provided evidence that the compound produced had antibacterial and anticancer properties. Cotton fabrics have the highest staining capacity for crude mycobial pigment, which is fast and exhibited negative cytotoxicity. This is the rst report from novel microorganism N. oryzae.

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Bioprospecting potential and textile dyeing of Mycobial red pigment from novel microorganism Nigrospora oryzae

Mani

Thangavel

Sneha

et al. 2023

Preprint

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Natural pigments are getting prominence because of the hazardous effects from the use of synthetic colouring chemicals. Microbial pigments, in addition to their vast biological activities, provide an easily accessible alternative supply of natural colours. A total of twenty-four fungal cultures were isolated from the leaf tissues of Senna auriculata, out of which a distinctive strain (FNG1) exhibited an extracellular pigmentation of reddish orange. The isolate was identified as Nigrospora oryzae based on morphological traits and a molecular phylogenetic study of a combined Internal Transcribed Spacer (ITS) and β- tubulin analysis. The crude red pigment was the most soluble in ethyl acetate. The natural pigment was characterised and partly purified using thin-layer chromatography. As a result, the partly purified fungal pigment Ergo, was used in further bioprospecting investigations. The antimicrobial activity of the partly purified sample was evaluated against eight human pathogens, with the maximum zone of inhibition identified in Leucobacter AA7 (200–500 µg/mL). DPPH scavenging activity of the compound increased from 38.2–67.9% with an IC50 value of 34.195 ± 2.33 µg/mL. The cytotoxicity of partially purified fungal pigment inhibited cancer cells while having little effect on non-cancerous HEK293 T cells. The gas chromatography–mass spectrometry (GC–MS) provided evidence that the compound produced had antibacterial and anticancer properties. Cotton fabrics have the highest staining capacity for crude mycobial pigment, which is fast and exhibited negative cytotoxicity. This is the first report from novel microorganism N. oryzae.

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New insights into the identification of bioactive compounds from Willughbeia edulis Roxb. through GC–MS analysis

Cited by 3 publications

References 12 publications

CHARACTERIZATION OF ANTIOXIDANT COMPOUNDS FROM CELEBES SEA BAMBOO EXTRACTS (Isis hippuris) USING GC-MS

CHARACTERIZATION OF ANTIOXIDANT COMPOUNDS FROM CELEBES SEA BAMBOO EXTRACTS (Isis hippuris) USING GC-MS

Unveiling the Bioprospecting Efficacy and Textile Dyeing of a Novel Endophytic Mycobial Red Pigment

Bioprospecting potential and textile dyeing of Mycobial red pigment from novel microorganism Nigrospora oryzae

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