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Cited by 176 publications
(133 citation statements)
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References 191 publications
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“…Signaling by GPCRs was long thought to be either on (agonist bound) or off. However, more recent data have made clear that the receptor states of many (if not all) GPCRs are much more variable, which also applies to the classification of the different kinds of ligands that interact and regulate GPCR functions (4,5). This is illustrated by the fact that some agonists activate the targeted receptor to trigger all effector/ second messenger systems coupled to that particular receptor, whereas others are biased signaling agonists that give rise to a functional selective or biased response (4,6).…”
mentioning
confidence: 99%
“…Signaling by GPCRs was long thought to be either on (agonist bound) or off. However, more recent data have made clear that the receptor states of many (if not all) GPCRs are much more variable, which also applies to the classification of the different kinds of ligands that interact and regulate GPCR functions (4,5). This is illustrated by the fact that some agonists activate the targeted receptor to trigger all effector/ second messenger systems coupled to that particular receptor, whereas others are biased signaling agonists that give rise to a functional selective or biased response (4,6).…”
mentioning
confidence: 99%
“…The intracellular GPCR phosphorylations induced following their agonist occupation are mediated by GPCR kinases (GRKs) that create “barcodes” for induction of different signaling pathways . The phosphorylations can alternatively bias signaling via the G protein versus the β‐arrestin pathway . Six GRKs have been defined and three (GRK2, and GRK5/6) generate the barcode that recruits β‐arrestin .…”
Section: Resultsmentioning
confidence: 99%
“…We found that HG inhibited the PE‐induced phosphorylation of ERK1/2. GPCR can directly couple not only to G protein but also to other signaling molecules, such as arrestins (Latorraca et al, ; Wang, Qiao, & Li, ). Ligands can “bias” downstream signaling of different processes.…”
Section: Discussionmentioning
confidence: 99%
“…We found that HG inhibited the PEinduced phosphorylation of ERK1/2. GPCR can directly couple not only to G protein but also to other signaling molecules, such as arrestins (Latorraca et al, 2018;Wang, Qiao, & Li, 2018 could potentially have vasorelaxant effects from the antagonization of α 1 -AR. Indeed, our studies provided strong clues for this possibility.…”
Section: Effect Of Hg On Arterial Pressurementioning
confidence: 99%