New insight into calcinosis of juvenile dermatomyositis: A study of composition and treatment

Mukamel, Masza; Horev, Gadi; Mimouni, Marc

doi:10.1067/mpd.2001.112473

Cited by 141 publications

(81 citation statements)

References 17 publications

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“…As calcinoses podem ainda causar atrofia muscular secundária, contraturas articulares e úlceras cutâneas com episódios recorrentes de inflamação ou infecção local e extrusão de material cálcico e purulento da lesão (2) . Estudo do material da calcinose mostrou presença de macrófagos, interleucinas 1β (IL-1β), 6 (IL-6) e fator de necrose tumoral α (TNF-α) (2,3) . A FOP é uma doença genética rara do tecido conjuntivo, caracterizada por ossificação disseminada em tecidos moles e alterações congênitas das extremidades.…”

Section: Discussionunclassified

“…Pode ser dolorosa e muito debilitante, resultando, às vezes, em incapacidade funcional. A patogênese é desconhecida, mas parece envolver a ação de células inflamatórias, citocinas e proteínas da matriz mineralizada, como osteocalcina, entre outras (3) . Atraso no início do tratamento, vasculopatia e doença grave são fatores de risco para o aparecimento de calcinose nesses pacientes (4)(5)(6) .…”

Section: Introductionunclassified

“…Calcinose na Infância, um Desafio Terapêutico Calcinosis in Juvenile Dermatomyositis, A Therapeutic Challenge Tânia Caroline Monteiro de Castro (1) , Edson Yamashita (2) , Maria Teresa R. A. Terreri (3) , Claúdio Arnaldo Len (4) , Maria Odete Esteves Hilário (5) Os autores relatam e discutem o uso de algumas dessas medicações, como o alendronato, o diltiazen e a imunoglobulina endovenosa (IGEV) no tratamento da calcinose em dois pacientes com DMJ e fazem uma revisão da literatura das medicações mais utilizadas nesta que é a seqüela mais característica e a menos compreendida da DMJ.…”

Section: Introductionunclassified

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Calcinose na infância, um desafio terapêutico

Castro

Yamashita

Terreri

et al. 2007

Rev. Bras. Reumatol.

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A calcinose é uma complicação comum e incapacitante da dermatomiosite. Ela constitui uma característica marcante da doença, ocorrendo principalmente em pacientes pediátricos. Pouco se sabe a respeito de sua fisiopatologia e não existe um tratamento reconhecido universalmente. Este trabalho relata dois casos de dermatomiosite juvenil e calcinose grave com melhora clínica com o uso do alendronato e do diltiazen em um paciente e da imunoglobulina endovenosa em outro.Palavras-chave: dermatomiosite juvenil, calcinose, alendronato, diltiazen, imunoglobulina. ABSTRACTCalcinosis is a common and debilitating complication of dermatomyositis. It is a hallmark of the disease, occurring mainly in pediatric patients. Little is known about its pathophysiology, and there is no universally recognized treatment. This is a report of two children with juvenile dermatomyositis and severe calcinosis who showed improvement with the use of alendronate and diltiazen in one patient, and intravenous immunoglobulin in the other.

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Section: Discussionunclassified

Section: Introductionunclassified

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Calcinose na infância, um desafio terapêutico

Castro

Yamashita

Terreri

et al. 2007

Rev. Bras. Reumatol.

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“…6 In a recent report, macrophages and proinflammatory cytokines, including Il-6, Il-1 and TNF-a, were present in the milk of calcium fluid examined from a patient. 7 Calcinosis has also been more frequently associated with the TNF-a-308A promoter polymorphism, which is associated with increased TNF-a production by peripheral blood mononuclear cells. 8 Recent reports suggest that the early initiation of intensive anti-inflammatory therapy for JDM may be effective in preventing the future development of calcinosis.…”

Section: Discussionmentioning

confidence: 99%

Disappearance of diffuse calcinosis following autologous stem cell transplantation in a child with autoimmune disease

Elhasid

Rowe

Berkowitz

et al. 2004

Bone Marrow Transplant

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Summary:A 12-year-old girl presented with arthritis, myalgia, anemia and positive ANA. Subsequently, she developed recurrent episodes of pulmonary hemorrhage, thrombocytopenia, CNS abnormalities, skin ulcers and diffuse calcinosis. This was followed by secondary antiphospholipid syndrome. Despite vigorous immunosuppression, the patient became bedridden. A peripheral blood stem cell autograft was offered when she developed pulmonary hypertension and digital ischemia at the age of 16 years. The post-transplantation course was uneventful. Liquefaction of calcinosis nodules with improvement of mobility occurred gradually. She is now 24 months post-transplant with no sign of disease activity and total disappearance of calcinosis nodules.

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“…Various therapies have been tried, including low-dose warfarin, colchicine, probenecid, diltiazem, aluminum hydroxide, alendronate, intravenous methylprednisolone and surgical excision [126][127][128][129][130][131][132][133][134][135][136]. Infliximab also showed benefit in some patients with juvenile DM and calcinosis in one study [82].…”

Section: Therapy For Calcinosismentioning

confidence: 99%