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Cited by 11 publications
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“…Previous studies have reported that the dichloromethane extract of this plant showed mediocre antiviral activity with cytotoxic properties [4]. The leaves of the plant contain Ingenol esters [5], which induce apoptosis (anticancer, and anti-HIV properties) as reported by Blanco-Molina et al 2001 [6]. Spectroscopic analysis of leaves and small branches of the plant detected seventeen polyphenols including two new ellagitannins, and a trigalloylglucopyranose [7].…”
Section: Introductionmentioning
confidence: 82%
“…Previous studies have reported that the dichloromethane extract of this plant showed mediocre antiviral activity with cytotoxic properties [4]. The leaves of the plant contain Ingenol esters [5], which induce apoptosis (anticancer, and anti-HIV properties) as reported by Blanco-Molina et al 2001 [6]. Spectroscopic analysis of leaves and small branches of the plant detected seventeen polyphenols including two new ellagitannins, and a trigalloylglucopyranose [7].…”
Section: Introductionmentioning
confidence: 82%
“…Many of the euphorbia compounds have been examined for their toxicity or their potential activity [26]. The literature review of E. cotinifolia has revealed the isolation and characterization of new ingenol esters from methanolic extract [10], which possess piscicidal constituents, two new ellagi tannins, and a trigalloylglucoseyl kaempferol from E. cotinifolia extract possessing antitumor and antioxidant activity indicating the potential of E. cotinifolia. The study by Runyoro and team [27] determined the antifungal activity and brine shrimp lethality of the latex, methanolic leaf, and stem bark extracts of Euphorbia cotinifolia and leaves extracts inhibited Trichophyton mentagrophytes, Trichophyton rubrum, and Aspergillus niger with inhibition zones of 12, 17, and 15 mm, respectively, and 9 mm for both fungi with stem bark extracts, while the MICs ranged from 2.5 to 5 mg/ml.…”
Section: Discussionmentioning
confidence: 99%
“…MS, m/z: 472 (M + ). Based on the above data, the name of the compound 1 is given as 5-hydroxy-4-(2-methoxy-2-oxoethyl)-1,1,7-trimethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta [a]cyclopropa[e] [10]annulen-6-yl heptanoate ( Fig. 1; Tables 6 and 7).…”
Section: Characterization Of Active Compounds Of E Cotinifoliamentioning
confidence: 99%
See 1 more Smart Citation
“…For the resolution of racemic 2-methylbutanoic acid, the procedure reported by Hirota et al (1980) was used to hydrolyze the amide from 2-methylbutanoic acid and S-␣-methylbenzylamine, by using 6 N HCl. The preparation of 2-methylbutanoate from alcohols and acids of various stereochemistry were as described by Ho et al (2009).…”
Section: Methodsmentioning
confidence: 99%