New imidazo[1,2-b]pyrazoles as anticancer agents: Synthesis, biological evaluation and structure activity relationship analysis

Recent Reports on Pyrazole-Based Bioactive Compounds as Candidate for Anticancer Agents

“…The structure-activity relationship analysis resulted preliminary conclusion that C-7 aminomethylated compounds containing 6-membered cycle like N-methylpiperazine or morpholine have high anticancer potency. On the contrary, in C-2/C-3/C-6/C-7 tetrasubstituted imidazo[1,2-b]pyrazoles, the presence of a fourth substituent has not influence to enhance the anticancer activity, except in the case of compound 20 [26].…”

“…The cytotoxic activities were evaluated in vitro against four human cancer cell [26]. Of the 39 compounds screened in vitro by MTT assay, compound 18a, 18b, 19, and 20 displayed an IC 50 below 10 µM.…”

3-[(3,5-Dimethyl-1H-pyrazol-1-yl)methyl]-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione

“…They exhibit anti-bacterial, anti-depressant (Liu et al, 2008;Yhya et al, 2012), anti-oxidant (Abdel-Aziz et al 2009), anti-cancer (Grosse et al, 2014) and anti-viral activities (Hamdy & El-Senousy, 2013) in addition to their anti-inflammatory and anti-microbial activities. Moreover, pyrazoles containing 4-substituted-1,2,4-triazole-3-thiones have been reported to possess anti-inflammatory activities (El-Moghazy et al, 2012).…”

Etidronic Acid Promoted Sequential One‐Pot Strategy for the Synthesis of 1H‐Imidazo[1,2‐b]pyrazoles: A Green Catalyst for Groebke‐Blackburn‐Bienaymé Reaction

“…Development of multi‐component reactions based approach to synthesis of imidazopyrazoles derivatives, as one of the most important fused heterocyclic compounds for drug discovery . Since many compounds incorporating these scaffolds exhibit a wide range of biological, medicinal, and pharmaceutical activities, such as anticancer, anti‐inflammatory, antiviral in Herpes Simplex Virus type‐1, and anti‐neoplastic with L1210 leukemia‐cells .…”