2010
DOI: 10.1038/ng.520
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Abstract: Circulating glucose levels are tightly regulated. To identify novel glycemic loci, we performed meta-analyses of 21 genome-wide associations studies informative for fasting glucose (FG), fasting insulin (FI) and indices of β-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 non-diabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with FG/HOMA-B and two associated with FI/HOMA-IR. These include nine new FG loci (in or near ADCY5, MAD… Show more

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Cited by 1,946 publications
(2,176 citation statements)
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References 73 publications
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“…We also examined the associations of the IGF‐I‐ and IGFBP‐3‐associated SNPs with anthropometric traits (height, BMI, waist‐to‐hip ratio, and fat percentage) (Heid et al ., 2010; Lango Allen et al ., 2010; Speliotes et al ., 2010), bone mineral density (Estrada et al ., 2012), risk of type 2 diabetes (Voight et al ., 2010; Morris et al ., 2012) and related traits (fasting glucose, 2‐h glucose, HbA1c, fasting insulin, proinsulin, HOMA‐IR, and HOMA‐B) (Dupuis et al ., 2010; Saxena et al ., 2010; Soranzo et al ., 2010), and coronary artery disease (Coronary Artery Disease Genetics C, 2011; Schunkert et al ., 2011; Consortium CAD and Deloukas, 2013) (Table S9, Supporting information). Many nominal associations were expected because of the known influence of the IGF system on these traits.…”
Section: Resultsmentioning
confidence: 99%
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“…We also examined the associations of the IGF‐I‐ and IGFBP‐3‐associated SNPs with anthropometric traits (height, BMI, waist‐to‐hip ratio, and fat percentage) (Heid et al ., 2010; Lango Allen et al ., 2010; Speliotes et al ., 2010), bone mineral density (Estrada et al ., 2012), risk of type 2 diabetes (Voight et al ., 2010; Morris et al ., 2012) and related traits (fasting glucose, 2‐h glucose, HbA1c, fasting insulin, proinsulin, HOMA‐IR, and HOMA‐B) (Dupuis et al ., 2010; Saxena et al ., 2010; Soranzo et al ., 2010), and coronary artery disease (Coronary Artery Disease Genetics C, 2011; Schunkert et al ., 2011; Consortium CAD and Deloukas, 2013) (Table S9, Supporting information). Many nominal associations were expected because of the known influence of the IGF system on these traits.…”
Section: Resultsmentioning
confidence: 99%
“…Top SNPs associated with levels of IGF‐I and IGFBP‐3 were examined in relationship to other phenotypes using published data on serum metabolites (Suhre et al ., 2011; Shin et al ., 2014), anthropometric traits (Heid et al ., 2010; Lango Allen et al ., 2010; Speliotes et al ., 2010), bone mineral density (Estrada et al ., 2012), diabetes (Voight et al ., 2010; Morris et al ., 2012) and glycemic traits (Dupuis et al ., 2010; Saxena et al ., 2010; Soranzo et al ., 2010), coronary artery disease (Coronary Artery Disease Genetics C, 2011; Schunkert et al ., 2011; Consortium CAD and Deloukas, 2013), and survival beyond 90 years (Broer et al ., 2015). Detailed information of the published datasets used including its references is given in Table S9 (Supporting information).…”
Section: Methodsmentioning
confidence: 99%
“…Il est important de noter que nous n'avons observé aucune corré-lation entre l'amplitude de l'effet sur la variabilité de la glycémie et l'association avec le DT2. Les deux exemples les plus frappants étant ceux des locus G6PC2 (glucose-6-phosphatase, catalytic, 2) …”
Section: Les Déterminants De La Glycémie Et De L'insulinémie Augmenteunclassified
“…Dans cette nouvelle, j'aborderai les résultats majeurs de la dernière publication MAGIC [1] qui apporte de nouveaux éclairages sur les voies biologiques impliquées dans le déterminisme génétique de la glycémie et de l'insulinémie. 1 www.magicinvestigators.org Objectif et stratégie de l'étude MAGIC a été à l'origine de plusieurs méta-analyses qui ont identifié jusqu'à présent 16 locus associés avec la glycémie à jeun, deux avec l'insulinémie et cinq avec la glycémie postprandiale [2,3]. Cependant, si la composante génétique de ces traits -ou héritabilité -est estimée entre 30 et 60 %, ces locus ne peuvent suffire à expliquer la part génétique de ces traits.…”
unclassified
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