New flavonol methyl ether from the leaves of Vitex peduncularis exhibits potential inhibitory activity against Leishmania donovani through activation of iNOS expression

Rudrapaul, Prasenjit; Sarma, Indrajit Sil; Das, Niranjan; De, Utpal Chandra; Bhattacharjee, Surajit; Dinda, Biswanath

doi:10.1016/j.ejmech.2014.09.076

Cited by 29 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous phytochemical studies showed that the plant, V. peduncularis is known to be a source of flavonoids, iridoids, triterpenoids and flavonol methyl ether (Sharma, 1955;Rao and Venkateswarlu, 1962;Sahu et al, 1984;Suksamrarn et al, 2002;Rudrapaul et al, 2014). In the present study, Isolation of epifriedelinol (CAS# 16844-71-6) from the leaves of V. peduncularis and the crystal structure and molecular and its antibacterial activity of the compound are reported.…”

Section: Introductionmentioning

confidence: 63%

Crystal structure and antibacterial evaluation of epifriedelinol isolated from Vitex peduncularis Wall. ex Schauer

Kannathasan

Senthilkumar

Venkatesalu

2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

Epifriedelinol, an antibacterial pentacyclic triterpene was isolated from the methanol extract of Vitex peduncularis by bio-assay guided separation and the structure of the compound was elucidated by various spectroscopic methods such as 1 H NMR, 13 C NMR and single crystal X-ray Diffraction. The antibacterial activity of epifriedelinol was examined against five species of Gram positive and seven strains of Gram negative bacteria. The presence of epifriedelinol in V. peduncularis and its antibacterial activity were reported for the first time. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

show abstract

Section: Introductionmentioning

confidence: 63%

Crystal structure and antibacterial evaluation of epifriedelinol isolated from Vitex peduncularis Wall. ex Schauer

Kannathasan

Senthilkumar

Venkatesalu

2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…Compound 2 was also obtained as a yellowish powder and the molecular formula was determined to be C 18 H 16 . [4] All NMR assignments of 2 were confirmed by detailed analyses of HSQC and HMBC spectra. The HMBC correlation between H-6 ( H 6.37)/H-8 ( H 6.75) and C-7 ( C 165.1); methoxy proton (δ H 3.81) and C-3 (δ C 138.0); and between methoxy proton (δ H 3.87) and C-7 ( C 165.1) suggested the positions of two methoxy groups at C-3 and C-7.…”

Section: Figurementioning

confidence: 83%

“…The HMBC correlations between H-6 ( H 6.36)/H-8 ( H 6.73) and C-7 ( C 165.1); methoxy proton (δ H 3.80) and C-3 (δ C 137.8); and between methoxy proton and C-7 ( C 165.1) suggested the positions of two methoxy groups at C-3 and C-7. All NMR assignments of 1 were confirmed by detailed analyses of HSQC and HMBC spectra (table 1), [3] , ¥ δC of vitecetin [4] , $ δC of 5,4′-dihydroxy-7,3′-dimethoxyflavone [5] , @ δC of maltol O-β-D-glucopyranoside [6] .…”

Section: Extraction and Isolationmentioning

confidence: 90%

“…Thus, compound 2 was identified as vitecetin and this compound was already reported from Vitex peduncularis. [4] The 1 H-NMR spectrum of 3 showed the following proton signals: three aromatic protons with ABX system of B ring at δ H 7.57 (1H, s), 7.58 (1H, d, J = 7.5 Hz), and 6.94 (1H, d, J = 7.5 Hz), two meta aromatic protons of A ring at 6.35 (1H, s) and 6.93 (1H, s), one proton of C ring at δ H 6.76 (1H, s), and two methoxy groups at  H 3.86 (3H, s) and 3.90 (3H, s). The 13 C-NMR and DEPT spectra of 3 showed signals of 17 carbons, including nine non-protonated carbons, six methines and two methoxy carbons.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Flavonoids and other compounds from Vitex limonifolia

Thoa

Ban

Trang

et al. 2018

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

Using combined chromatographic methods, three flavonoids, 5,4′-dihydroxy-3,7-dimethoxyflavone (1), vitecetin(2), 5,4′-dihydroxy-7,3′-dimethoxyflavone (3), a lignan, verrucosin (4), and a -pyrone glycoside, maltol O-β-Dglucopyranoside (5) were isolated from the methanol extract of the leaves of Vitex limonifolia. Their structures were identified on the basis of spectroscopic evidence and comparison with those reported in the literature. Compounds 1 and 3-5 were reported from Vitex genus for the first time.

show abstract

“…An infusion of leaves or root bark or young stem bark is used as a cure in several classes of malarial fever, mainly black water fever (Sharma et al 2001; Kirtikar et al 1918;Vaughan, 1921). The plant also exhibits potential inhibitory activity against kala-azar in human (Rudrapaul et al 2014). The decoction of bark is used to cure typhoid fever (Lalfakzuala et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Germination and initial seedling growth performance of Vitex peduncularis Wall. ex Schauer – A threatened native tree species of Bangladesh

Hasnat¹,

Hossain²,

Alam³

et al. 2019

J biosci agric res

View full text Add to dashboard Cite

Vitex peduncularis Wall. ex Schauer, locally known as Goda, is a threatened native tree species of Bangladesh. In addition to providing many other services this produces, timber of high density, which is traditionally, used for different construction activities. Though seed production is regular but natural germination of seeds is not satisfactory due to the hard seed coat. Effect of pre-sowing methods was studied to find out the best pre-sowing method for higher rate of V. peduncularis seeds germination. Randomly selected quality seeds were sown in propagator house with Sylhet sand media, in conventional polybags with 3:1 soil and cow-dung media, and in nursery beds with soil media only. Significantly (P<0.05) highest seed germination (46%) was observed in propagator house. The germination energy (7.9%), plant percent (31.5%) and germination value (147.2) were highest in the seedlings raised in polybags. These seedlings also exhibited better growth in the initial stage at nursery. The records of initial growth of the seedlings indicated highest shoot length (38 cm), root length (34.3 cm), node number (15) and leaf area (18.9 cm × 4.7 cm) for seedlings grown in polybags. Seedlings grown in polybags were more vigor and thrive better than the seedlings germinated in propagator house and nursery bed. This paper will be a supportive material for more advanced studies on seed germination and for establishing plantation with rare but valuable species by raising commercial nurseries.

show abstract

New flavonol methyl ether from the leaves of Vitex peduncularis exhibits potential inhibitory activity against Leishmania donovani through activation of iNOS expression

Cited by 29 publications

References 25 publications

Crystal structure and antibacterial evaluation of epifriedelinol isolated from Vitex peduncularis Wall. ex Schauer

Crystal structure and antibacterial evaluation of epifriedelinol isolated from Vitex peduncularis Wall. ex Schauer

Flavonoids and other compounds from Vitex limonifolia

Germination and initial seedling growth performance of Vitex peduncularis Wall. ex Schauer – A threatened native tree species of Bangladesh

Contact Info

Product

Resources

About