New expectations from the well-known medicinal properties of Arctium lappa

Miele, Claudia; Béguinot, Francesco

doi:10.1007/s00125-012-2503-7

Cited by 12 publications

(8 citation statements)

References 20 publications

(31 reference statements)

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“…In fact, glyphosate-based herbicides such as R potently affect the cardiovascular system in mammals [ 42 ]. Arctigenin present in D (in Arctium lappa ) activates muscle uptake of glucose [ 43 ], which could restore the locomotor activity. Berbamine (in Berberis vulgaris ) may modulate myocardial contractility [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup

Gress

Laurant²,

Defarge

et al. 2016

BMC Complement Altern Med

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BackgroundPlant medicinal extracts may be claimed to prevent or cure chemical intoxications. Few of these are tested for their mechanisms of actions in vivo and for their cellular impacts. In 2011, we demonstrated that hepatic cell mortality induced by environmentally realistic levels of the widely used herbicide Roundup (R) in vitro can be almost entirely prevented by plant extracts called Dig1 (D, Digeodren).MethodsWe tested the in vivo effects of D alone (1.2 ml/kg bw/d), but also prior to and during 8 days of R intoxication (at 135 mg/kg bw/d) in a total of 4 groups of 40 adult Sprague-Dawley male rats each. After treatments, horizontal and vertical locomotor activities of the animals were measured by use of actimeters. Brain, liver, kidneys, heart and testes were collected and weighted. Body weights as well as feed and water consumption were recorded. Proteins, creatinine, urea, phosphate, potassium, sodium, calcium, chloride ions, testosterone, estradiol, AST and ALT were measured in serum. In liver S9 fractions, GST, GGT, and CYP450 (1A2, 2C9, 2C19, 2D6, 3A4) were assessed.ResultsD did not have any physiological or biochemical observable impact alone at 2 %. Out of a total of 29 measured parameters, 8 were significantly affected by R absorption within only 8 days. On these 8 parameters, only 2 were not restored by D (GGT activity and plasmatic phosphate), 5 were totally restored (horizontal and vertical locomotor activities, CYP2D6 activity, plasmatic Na + and estradiol), and the 6th was almost restored (plasmatic K+). The specificities of the toxic effects of R and of the therapeutic effects of D treatment were thus demonstrated, both at the behavioural and biochemical levels.ConclusionsD, without any side effect observable in these conditions, presented strong preventive and therapeutic properties in vivo after a short-term intoxication by the widely used pesticide Roundup.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1226-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup

Gress

Laurant²,

Defarge

et al. 2016

BMC Complement Altern Med

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“…These findings also need to be investigated further as to explain why there was loss present in subcutaneous fat but not visceral fat as well as no net weight loss despite decrease in subcutaneous fat. Arctigenin holds promise as a potent antidiabetic drug, but all dimensions of arctigenin need to be explored with respect to its beneficial effect on diabetes (Huang et al, 2012;Miele & Beguinot, 2012 Furthermore, Ss showed potent antioxidant ability that helped in counteracting the effects of diabetes and also blocked gluconeogenesis in diabetic mice (Zhao et al, 2017).…”

Section: Articum Lappamentioning

confidence: 99%

Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications

Joshi

Singh

Haratipour

et al. 2019

Journal Cellular Physiology

127

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Diabetes affects a large population of the world. Lifestyle, obesity, dietary habits, and genetic factors contribute to this metabolic disease. A target pathway to control diabetes is the 5′‐adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway. AMPK is a heterotrimeric protein with α, β, and γ subunits. In several studies, AMPK activation enhanced glucose uptake into cells and inhibited intracellular glucose production. Impairment of AMPK activity is present in diabetes, according to some studies. Drugs used in the treatment of diabetes, such as metformin, are also known to act through regulation of AMPK. Thus, drugs that activate and regulate AMPK are potential candidates for the treatment of diabetes. In addition, many patients encounter important adverse effects, like hypoglycemia, while using allopathic drugs. As a result, the investigation of plant‐derived natural drugs that lack adverse side effects and treat diabetes is necessary. Natural products like berberine, quercetin, resveratrol, and so forth have shown significant potential in regulating and activating the AMPK pathway which can lead to manage diabetes mellitus and its complications.

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“…Synergistisch dazu verbessert das Lignan Arctigenin in an Adipositas leiden den Versuchstieren den Glukose und Fettstoffwechsel. Dabei wird mit der AMPaktivierten Proteinkinase ein attrak tives Zielenzym induziert, das auch ein therapeutisches Target für neue Antidia betika darstellt und eine Verminderung der viszeralen Fettmasse ermöglichen soll (41).…”

Section: Weitere Wirkungenunclassified

Kann man mit Fischen gegen Multiple Sklerose anschwimmen?

Baumgarten¹,

Melzig²

2014

EHK

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Zusammenfassung Arctium lappa L. ist eine seit der Antike verwendete Arzneipflanze. In der traditionellen europ?ischen als auch traditionellen chinesischen Medizin werden v.a. Samen und Wurzeln zur topischen Anwendung bei Erkrankungen der Haut, als entz?ndungshemmende und antibakterielle Zubereitungen eingesetzt. Als pharmakologisch aktive Inhaltsstoffe wurden die Lignane Arctigenin und Diarctigenin charakterisiert. Das in der Wurzel enthaltene Inulin kann bei Darmtr?gheit eingesetzt werden. Das Inhaltsstoffspektrum umfasst weiterhin Hydroxyzimts?urederivate, Sterole und Polyine. Die Arzneipflanze findet heute v. a. Anwendung in der Hom?opathie und Kosmetik.

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New expectations from the well-known medicinal properties of Arctium lappa

Cited by 12 publications

References 20 publications

Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup

Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup

Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications

Kann man mit Fischen gegen Multiple Sklerose anschwimmen?

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