New device for intraoperative graft assessment: HyperEye charge-coupled device camera system

Handa, Takemi; Katare, Rajesh; Nishimori, Hideaki; Wariishi, Seiichiro; Fukutomi, Takashi; Yamamoto, Masaki; Sasaguri, Shiro; Sato, Takayuki

doi:10.1007/s11748-009-0536-8

Cited by 68 publications

(31 citation statements)

References 17 publications

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“…Furthermore, recently there has been considerable focus on the potential use of ICG in intra-operative real-time imaging. [43][44][45][46][47][48][49] The combined use of ICG and near-infrared light could be a novel therapeutic system, including intra-operative imaging modalities and PDT. …”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis

Funayama

Sakane

Abe

et al. 2012

Photomedicine and Laser Surgery

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Objective: The purpose of this study was to investigate the phototoxic effects of photodynamic therapy (PDT) with indocyanine green (ICG) and near-infrared light irradiation on rat mammary adenocarcinoma cells, and its therapeutic efficacy in a rat model of spinal metastasis. Background data: Although PDT has been successfully used as a non-radiation treatment for many malignancies, it has not yet been clinically applied for treating spinal metastasis. Methods: For the phototoxicity study, CRL-1666 cells were treated with PDT and cell viability was measured by WST-1 assay. For the efficacy study, 26 female Fischer 344 rats with spinal metastasis in the L6 vertebra were divided into three treatment groups: PDT with local injection of ICG (9 rats), PDT with systemic injection of ICG (10 rats), and no treatment or control (7 rats). Both the PDT groups received near-infrared light irradiation with a total energy of 10 J (1 W for 10 sec). The light was delivered directly through a single silica probe which was set on the left side of the L6 vertebral body. Hindlimb motor function was monitored according to the Basso-Beattie-Bresnahan (BBB) scale. Further, the observation periods were calculated to determine the survival time. Results: The PDT exerted immediate and persistent phototoxic effects. Furthermore, the PDT with local injection of ICG as well as systemic injection of ICG delayed the deterioration of paralysis and prolonged the observation period. Conclusions: PDT with ICG injection and near-infrared light irradiation could be an effective local adjuvant treatment for spinal metastasis.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis

Funayama

Sakane

Abe

et al. 2012

Photomedicine and Laser Surgery

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“…Thus, the NIR fluorescence imaging may be suitable for intraoperative using, while it is not appropriate for screening of human body. Since a CCD camera and a microscope with an ICG filter, which enabled visualization of the invisible near-infrared light, have been previously used in surgery [11,12,[14][15][16], ICG-lactosome could function as a novel imaging probe, enabling the surgeon to easily diagnose the safety margin and small skip lesions intraoperatively.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, there has been considerable focus on the potential use of indocyanine green (ICG) in intraoperative real-time imaging [10][11][12][13][14][15][16]. However, the strong binding of plasma proteins with ICG and its subsequent rapid clearance by the liver results in binding of ICG to the tumor only for a short duration after administration; thus, the use of ICG for tumor imaging applications is limited [17].…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Near-infrared Fluorescence Imaging with Novel Indocyanine Green-Loaded Nanocarrier for Spinal Metastasis: A Preliminary Animal Study

Funayama¹,

Sakane²,

Abe³

et al. 2012

TOBEJ

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Abstract:Marginal resection during resection of a spinal metastasis is frequently difficult because of the presence of important tissues such as the aorta, vena cava, and dura mater, including the spinal cord adjacent to the vertebral body. Thus, there is an urgent need for novel intraoperative imaging modalities with the ability to clearly identify bone metastasis. We have proposed a novel nanocarrier loaded with indocyanine green (ICG) (ICG-lactosome) with tumor selectivity attributable to its enhanced permeation and retention (EPR) effect. We studied its feasibility in intraoperative near-infrared (NIR) fluorescence diagnosis with ICG-lactosome for imaging spinal metastasis. A rat model of subcutaneous mammary tumor and a rat model of spinal metastasis of breast cancer were used. Fluorescence emitted by the subcutaneous tumors and the spinal metastasis were clearly detected for at least 24 h. Moreover, imaging of the dissected spine revealed clear fluorescence emitted by the metastatic lesion in the L6 vertebra while the normal bone lacked fluorescence. This study was the first report on NIR fluorescence imaging of spinal metastasis in vivo. NIR fluorescence imaging with ICG-lactosome could be an effective intraoperative imaging modality for detecting spinal metastasis.

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“…Other related approaches employ Foveon X3 sensors (HyperEye Medical System, Mizuho Medical, Japan) 52 to detect unabsorbed NIR light or modify the Bayer filter pattern and filter the NIRF signal at the entrance to the sensor, 51 thus separation happens within the camera itself [see Fig. 2(c)].…”

Section: Software Control Computing Data Storage and Display Hardwarementioning

confidence: 99%

Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging

et al. 2016

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Abstract. There is growing interest in using fluorescence imaging instruments to guide surgery, and the leading options for open-field imaging are reviewed here. While the clinical fluorescence-guided surgery (FGS) field has been focused predominantly on indocyanine green (ICG) imaging, there is accelerated development of more specific molecular tracers. These agents should help advance new indications for which FGS presents a paradigm shift in how molecular information is provided for resection decisions. There has been a steady growth in commercially marketed FGS systems, each with their own differentiated performance characteristics and specifications. A set of desirable criteria is presented to guide the evaluation of instruments, including: (i) real-time overlay of white-light and fluorescence images, (ii) operation within ambient room lighting, (iii) nanomolar-level sensitivity, (iv) quantitative capabilities, (v) simultaneous multiple fluorophore imaging, and (vi) ergonomic utility for open surgery. In this review, United States Food and Drug Administration 510(k) cleared commercial systems and some leading premarket FGS research systems were evaluated to illustrate the continual increase in this performance feature base. Generally, the systems designed for ICG-only imaging have sufficient sensitivity to ICG, but a fraction of the other desired features listed above, with both lower sensitivity and dynamic range. In comparison, the emerging research systems targeted for use with molecular agents have unique capabilities that will be essential for successful clinical imaging studies with low-concentration agents or where superior rejection of ambient light is needed. There is no perfect imaging system, but the feature differences among them are important differentiators in their utility, as outlined in the data and tables here. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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New device for intraoperative graft assessment: HyperEye charge-coupled device camera system

Abstract: The HyperEye system can visualize any structural and functional failures. Our findings suggest that this device could become a useful tool for intraoperative graft assessment.

Cited by 68 publications

References 17 publications

Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis

Photodynamic Therapy with Indocyanine Green Injection and Near-Infrared Light Irradiation Has Phototoxic Effects and Delays Paralysis in Spinal Metastasis

Intraoperative Near-infrared Fluorescence Imaging with Novel Indocyanine Green-Loaded Nanocarrier for Spinal Metastasis: A Preliminary Animal Study

Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging

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