New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation

Metal complexes of novel Schiff base derived from iron sandwiched organometallic and 4‐nitro‐1,2‐phenylenediamine: Synthesis, characterization, DFT studies, antimicrobial activities and molecular docking

“…The first high intensity band was appeared at λ max = 276 nm may be attributed to the π‐π* transition of the aromatic rings. The second and third absorption bands that were showed at λ max = 328 and 418 nm attributed to the π‐π* transition of the azomethine group (C=N) and charge transfer, respectively . Electronic spectra of the complexes showed bands which were shifted from the free ligand to 262‐278 nm and 307‐333 nm for π‐π* of aromatic rings and π‐π* of azomethine transitions, respectively, confirming the coordination of the azomethine nitrogen to the metal ions.…”

“…Also the spectrum of ligand showed bands at 3432 and 3400 cm −1 which corresponding to ν(NH 2 ) group. Due to the presence of water molecules in the structure of all metal complexes, so these bands of amino group were included in a broad envelope band of OH group of these water molecules . Furthermore, it must be detect the ν(NH 2 ) bending band of all compounds.…”

A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells

“…It can be concluded that the effect of ligands and corresponding metal-complexes depends not only on the specific features in the auxiliary ligand and metal ion, but also on cancer cell type. Moreover, results from the last studies suggest that both ancillary ligand and intercalative ligand influence the degree of binding of these complexes to DNA as a result of which the majority of the metal-pyrazole complexes possessed anti-proliferative activities against cancer cell lines 15–17 . Additionally, various pyrazole and pyrazoline derivatives have been identified as inhibitors of cyclin-dependent kinase 18 and vascular endothelium growth factors 19 .…”

Novel synthesis of pyrazole-containing thiophene, 2-alkyloxy-pyridine and thieno[2,3-d]pyrimidine scaffolds as analgesic agents

“…Celecoxib and its derivatives are analgesic medicines with a pyrazole nucleus ( Figure 1). Diverse bioactive molecules are developed by pyrazole derivatives such as antibacterial, anti-inflammatory, antifungal, antiviral, antimicrobial,and anti-hyperglycemic properties [1][2][3][4][5][6][7][8][9][10]. Moreover, pyrazole-based heterocycles as thiophenes, 2-alkyloxypyridines and thieno [2,3-d]pyrimidines have been given more attention due to their useful therapeutic fields including, muscle relaxing, antitumor, anti-depressant, antimicrobial, antidiabetic, antitubercular, antioxidant, HIV reverse transcriptase inhibitors and also possess significant vasodilation activities [11][12][13][14][15][16][17].…”