New Creatinine Standard for Basal Metabolism and Its Clinical Application

Abstract

The study reported in this section of the present paper extended and confirmed previous investigations on the relation between creatinine excretion and basal energy metabolism.1 In a recent publicationlb two of us with F. Broughton presented a creatinine standard of metabolism which was based on a mixed group composed of "hospital normal" patients, normal children and normal adults. Those studies were carried further with the series of subjects reported on here. This group was made up entirely of normal school children and may therefore be considered ideal. Using the newer series alone, we prepared a new creatinine standard by statistical methods.The data were obtained from two groups of children who differed in age and socioeconomic status. The children composing the first group attended a private day school. Creatinine in the Urine: II. Prediction of Basal Heat Production from Creatinine, ibid. 56:965 (Nov.) 1938. 2. Other members of the research group and the school staff gave assistance in obtaining the cooperation of the children, and Miss Frances Broughton and Miss Penelope Hill gave technical assistance. Downloaded From: http://archpedi.jamanetwork.com/ by a Monash University Library User on 06/04/2015

Total body potassium and 24‐hour creatinine excretion in healthy males

“…4,6,7,10,11,13,15,20,21,30,37,42,46,47,49,54,57 Beard 3 claimed that there was no relationship between CR and basal metabolism, but there is adequate evidence to the contrary. 27,43,52,59,66,67 Recently, it has become evident that total body potassium (TBK) is a direct measure of metabolizing cell mass, 14,23,28,32,38,50,65 and in studies by Cheek 20 and by Graystone 38 TBK has shown high correlation (0.98) with CR in healthy youths of both sexes. We have taken the opportunity presented for us to measure and to compare TBK and CR in men and to determine the possibility that simple physical measurements might give a reasonably accurate, clinically useful predictor of CR.…”

Goitrous Hypothyroidism Simulating Thyrotoxicosis

“…Twenty-four-hour urinary excretion of creatinine 875 mg and of calcium 88 mg. B.M.R. 139 per cent of normal for age, 105 per cent when referred to creatinine standards of Talbot et al (8). X-ray of wrists for bone age 11-12 years.…”

“…That this case was regarded for four years as one of thyrotoxicosis was partly due to an apparently raised B.M.R., illustrating the unreliability in childhood of B.M.R.s related to age. Use of the creatinine standards of Talbot et al (8) led to the calculation of a B.M.R. which was a more accurate index of the thyroid state.…”