New concepts in the classification of cutaneous lymphomas

Willemze, R.

doi:10.1001/archderm.131.9.1077

Cited by 17 publications

(15 citation statements)

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“…For many decades, mycosis fungoides, Sézary syndrome, lymphomatoid papulosis and pagetoid reticulosis were the only cutaneous lymphomas that were clearly defined as entities [114,115]. Notifications of skin lymphomas which did not correspond to those mentioned above were casuistic rarities.…”

Section: Classifications Before the Mid-1970smentioning

confidence: 99%

“…The concepts of classifying cutaneous lymphoma were based on anatomical structures of the lymph node, which are not represented in the skin [114,115]. Clinical pictures of the skin, such as lymphomatoid papulosis, mycosis fungoides, pagetoid reticulosis and folliculotropic mycosis fungoides, have no nodal equivalent [116].…”

Section: Independent Classification For Cutaneous Lymphomasmentioning

confidence: 99%

“…In 1980, von Burg and Kerl [135] established the "EORTC cutaneous lymphoma task force" which, in 1982, now including more centers, acquired the project group status [140], whose main objectives were summarized by the Breur Committee in 1984 [141]. The classification by Willemze [114] in 1994, as a result of the Breur commission of the CTCL, represented the basis for the subsequent EORTC classification which corresponded approximately to the classification of Russell-Jones in 1996 [141]. It was based on the patient collective of all Dutch university hospitals and the university hospital of Ghent.…”

Section: Independent Classification For Cutaneous Lymphomasmentioning

confidence: 99%

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The History of Lymphoma Classifications with Special Consideration of Cutaneous Lymphomas

Niermann¹

2013

J Leuk

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For the modern evidence based medicine classification systems are necessary to guarantee a unifying approach for therapy and for prognosis of diseases. The comparability of clinical studies depends of the usage of adequate classification systems. But because all classifications are artificial, they only mirror the technical possibilities of its area.This review discusses the history of lymphoma classifications systems with a special focus on the topic of primary cutaneous lymphomas and the retikuloendothelial system. Furthermore special problems in terminology are discussed.clinical behavior and prognosis than histologically, cytomorphologically and immunohistochemically identical secondary cutaneous and nodal lymphomas [13]. However, for years the B-cell lymphomas in particular were divided into a classification system for nodal lymphomas which was partly not reproducible, resulting in serious consequences for treatment, which failed to meet the prognosis [13,14].

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Section: Classifications Before the Mid-1970smentioning

confidence: 99%

Section: Independent Classification For Cutaneous Lymphomasmentioning

confidence: 99%

Section: Independent Classification For Cutaneous Lymphomasmentioning

confidence: 99%

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The History of Lymphoma Classifications with Special Consideration of Cutaneous Lymphomas

Niermann¹

2013

J Leuk

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“…The Dutch Cutaneous Lymphoma Working Group recently published a specific classification for cutaneous T cell lymphomas (CTCL), based on both clinical and histopathological criteria. [4][5][6][7][8][9] Such classification has been recently proposed by the European Organization for Research and Treatment of Cancer (EORTC). 10 CTCL have been frequently suspected to be of viral origin.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases

et al. 1998

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Cutaneous T cell lymphomas (CTCL) are rare lymphoproliferative diseases, which are frequently suspected to be of viral origin. As very few data were available concerning cutaneous T cell lymphomas in tropical Africa, we undertook a clinical, histopathological, immunological and viro-molecular study of patients with a clinical diagnosis of cutaneous lymphoma, in Bamako, Mali. While prior to this study, no case of CTCL had been reported in this country, 14 patients (five women, nine men; mean age 58 years) with a diagnosis of cutaneous lymphoma were seen over a period of 30 months (1992-1994) in the only dermatological department in Mali. Clinically, the most frequent pattern was an infiltrated erythrodermia similar to Sezary syndrome. Nodular lesions and/or plaques were rarely observed. All these cutaneous tumors were T cell lymphoproliferations, only one expressing the CD8 + antigen. A comprehensive analysis of all the available data permitted characterization of three cases of adult T cell leukemia/lymphoma (ATL) associated with HTLV-I (one definitive case, of leukemic type, with demonstration of clonal integration of HTLV-I proviral genome and two probable ATL cases), three cases of Sezary syndrome (SS), two cases of mycosis fungoides (MF) and five cases of pleomorphic cutaneous lymphoma. In one case, the differentiation between MF and pleomorphic cutaneous lymphoma could not be established. HTLV-I serological and/or molecular markers were restricted to the three ATL cases. From the unique definitive ATL case, a T cell line was established from culture of peripheral blood mononuclear cells and sequence analysis of the env gene and the U3-LTR region demonstrated that the virus present in this patient belonged to the cosmopolitan subtype A. Thus, we report here the first evidence of HTLV-I infection and associated ATL in Mali. This is the second ATL case described for the whole Sahelian region (one ATL of the lymphoma type was reported previously in a Mauritanian patient). Furthermore, we demonstrate that the main types of CTCL described in Europe and North America are also present in this African area and that the prevalence of these diseases is greatly underestimated in such regions. Furthermore, no association was observed between HTLV-I/II infection and SS, MF or pleomorphic cutaneous lymphoma in Mali in contrast to other studies.

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“…It is very important to differentiate between the types, as they vary widely in terms of clinical behavior and prognosis. 17 CD30 is a surface glycoprotein that is often associated with large cell lymphoma. 18 Cardinal histological features of CD30 + CTCLs include dense dermal and/or subcutaneous infiltration by large lymphoid cells.…”

mentioning

confidence: 99%