New compounds from avocado pear

Kashman, Yoel; Néeman, I.; Lifshitz, A.

doi:10.1016/s0040-4020(01)83005-2

Cited by 74 publications

(64 citation statements)

References 5 publications

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“…1-3) by a polystyrene column (Diaion HP-20), activity was observed in the less polar fraction 2 eluted with MeOH. Fraction 2 was subjected to various kinds of chromatography to afford three 1,2,4-trihydroxyheptadec-16-ene derivatives (1-3), three 1,2,4-trihydroxyheptadec-16-yne derivatives (4-6), and two 1,2,4-trihydroxynonadecane derivatives (7,8). Compounds 1-7 were identified to be 1,2,4-trihydroxy-derivatives of C17 or C19 long-chain compounds by analyses of MS and NMR spectra as well as the comparison of physical data with those reported from fruits and seeds of the same plants.…”

Section: Resultsmentioning

confidence: 99%

“…Compounds 1-7 were identified to be 1,2,4-trihydroxy-derivatives of C17 or C19 long-chain compounds by analyses of MS and NMR spectra as well as the comparison of physical data with those reported from fruits and seeds of the same plants. [7][8][9][10][11][12] Compound 8 was obtained as a solid. The molecular formula of 8, two hydrogen less than 7, C 19 H 38 O 3 , was confirmed by HR-FAB-MS.…”

Section: Resultsmentioning

confidence: 99%

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Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana

Abe

Nagafuji

Okawa

et al. 2005

Biological & Pharmaceutical Bulletin

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As a preliminary screening test for the trypanocidal activity against epimastigotes of Trypanosoma cruzi in vitro, we examined some crude extracts of Mexican medicinal plants. 2)T. cruzi is the etiological agent for Chagas' disease (American trypanosomiasis), one of the most serious protozoan diseases in Latin America. Then we started on identification of the principal compounds of the active extracts seeking new chemotherapeutic agents for Chagas' disease. Lignans 2) from Guaco (roots of Aristolochia taliscana) and xanthones 3) from Bari (stems of Calophyllum brasiliense) were isolated as active components against epimastigotes in vitro.T. cruzi exhibits three developmental stages: epimastigote in the insect gut; trypomastigote, an infectious form in the mammalian blood stream; and an amastigote, a proliferative form in mammalian cells. In this paper we describe the results of continuous preliminary screening tests for trypanocidal activity against trypomastigotes as well as against epimastigotes in some Mexican plants.The edible fruit of Persea americana MILL. (Lauraceae), avocado, is grown throughout the tropics worldwides. The MeOH extract of seeds of Persea americana also showed moderate activity in the screening test. Herein we also describe the identification of the active constituents in seeds of P. americana. MATERIALS AND METHODS Plant Materials and Preparation of Their ExtractsPlant materials were mainly purchased at a medicinal plant market in Guadalajara, Jalisco, and collected in the fields. Identification of the plants was done by M. A. Martinez-Alfaro, one of the co-authors. The voucher specimens were deposited in the Herbarium of Jardín Botánico del Instituto de Biologia, Universidad Nacional Autonoma de Mexico.The plants examined are listed in Table 1 including those referred to in ref. 2. Dried and powdered materials were extracted with MeOH or MeOH-CH 2 Cl 2 at room temperature overnight. In the case of fresh materials, chopped materials were soaked in MeOH and filtered. The residue was extracted again with MeOH. The solvent was concentrated in vacuo to give each extract.Cultivation of T. cruzi The strain of T. cruzi used in this study and the cultivation method of epimastigotes were the same as those described in the previous paper.2) The trypomastigotes were harvested from the culture supernatant of rhesus monkey kidney (LLC-MK2) cells infected with T. cruzi as described in the previous paper.4,5) LLC-MK-2 cells were maintained in DMEM containing 10% FBS at 37°C under 5% CO 2 . After inoculation of trypomastigotes into LLC-MK2 cells, the medium was changed to DMEM containing 10% NCS.Instruments and Reagents The instruments and reagents used in this study are the same as those described in the preceding paper. 1)Trypanocidal Assay The detailed assay procedure against epimastigotes was described in the previous paper.2) The activity was expressed as the MC 100 value (mg/ml or mM), which was defined as the minimum concentration at which all the epimastigotes were terminated after incubation fo...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana

Abe

Nagafuji

Okawa

et al. 2005

Biological & Pharmaceutical Bulletin

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“…The amino acid citrulline in watermelon is a known stimulator of nitric oxide. Nitric oxide is known to relax and expand blood vessels much like the erectilw dysfunction drug Viagra and may increase libido [218]. The health benefit of watermelon fruit is associated with its status as a powerful antioxidants found in vit A, lycopene and beta carotene.…”

Section: Citrullus Lanatusmentioning

confidence: 99%

“…These compound classes may be divided into alkanols (also sometimes termed "aliphatic acetogenins"), terpenoid glycosides, various furan ring-containing derivatives, flavonoids, and a coumarin. The highly functionalized alkanols [218,[219][220][221] of avocado have exhibited quite diverse biological properties thus far. For example, Oberlies et al isolated 1, 2, 4-trihydroxyheptadec-16-ene, 1, 2, 4-trihydroxyheptadec-16-yne , and 1, 2, 4 -trihydroxynonadecane from the unripe fruits of P. americana, and found these substances to be moderately cytotoxic when evaluated against a small panel of cancer cell lines [219].Kawagishi et al isolated 5 alkanols from avocado fruits with "liver suppressing activity" (as determined by the changes in plasma levels of alanine aminotransferase and aspartate aminotransferase), including compounds 9-11 [221] Avocado has sometimes received the reputation as a fruit too high in fat.…”

Section: Persea Americanamentioning

confidence: 99%

Antioxidant Properties of Selected African Vegetables, Fruits and Mushrooms: A Review

Hamzah¹,

Jigam²,

Makun³

et al. 2013

Mycotoxin and Food Safety in Developing Countries

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“…200 species, the most well studied of these being P. americana Mill, known as "avocado fruit". Previous phytochemical studies on avocado seeds identified various classes of natural products such as phytosterols, triterpenes, 7 fatty acids with olefinic and acetylenic bonds, 8 alkylfurans, 9 dimers of flavanols, 10 oligomeric proanthocyanidins 11 and glucosylated abscisic acids. 12 Persea pyrifolia is popularly known as maçaranduba and it is frequently employed in the furniture manufacturing industry.…”

Section: Introductionmentioning

confidence: 99%

Aromatic compounds from three Brazilian Lauraceae species

Batista¹,

Batista²,

López³

et al. 2010

Quím. Nova

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INTRODUCTIONThe Lauraceae family comprises 52 genera and approximately 3000 species, mostly from tropical and warm subtropical regions of the world.1 Lauraceae species present several groups of secondary metabolites, most of them aromatic, which seem to be relevant for chemotaxonomic classification in Lauraceae. 2The genus Ocotea comprises ca. 350 species. Previous phytochemical studies have revealed the presence of neolignans, benzylisoquinoline alkaloids, phenylpropanoids, flavonoids and sesquiterpenes, 3 besides a variety of volatile components from its essential oils.1 Ocotea elegans is known as canela de ferro or canela preta in Brazil where it is widespread. Despite its huge distribution, the only study performed on O. elegans reports the isolation of neolignans from the stems by using countercurrent chromatography. 4 Ocotea corymbosa is popularly known as canela de corvo or canela fedorenta in Brazil and its wood is employed in the civil construction industry. 5 Only two studies were performed on O. corymbosa; monoterpenes and sesquiterpenes as well as phytosterols were isolated from the unripe fruits 3 and sesquiterpenes with calamenene skeleton were characterized from its bark. Persea is a genus that comprises ca. 200 species, the most well studied of these being P. americana Mill, known as "avocado fruit". Previous phytochemical studies on avocado seeds identified various classes of natural products such as phytosterols, triterpenes, 7 fatty acids with olefinic and acetylenic bonds, 8 alkylfurans, 9 dimers of flavanols, 10 oligomeric proanthocyanidins 11 and glucosylated abscisic acids. 12 Persea pyrifolia is popularly known as maçaranduba and it is frequently employed in the furniture manufacturing industry. 13 The only study carried out on P. pyrifolia dealt with volatile compounds from the leaves. 14 As part of our on-going program devoted to phytochemical investigations on Brazilian Lauraceae species, in this work we report the isolation of an ester of the 4-O-E-caffeoylquinic acid (1) and three flavonoids (2-4) from O. corymbosa, an aromatic sesquiterpene (5) and a flavonoid (6) from O. elegans as well as four furofuran lignans (7-10) from P. pyrifolia. This is the first chemical study on the leaves of O. elegans and O. corymbosa as well as the first report of nonvolatile compounds from P. pyrifolia. EXPERIMENTAL GeneralAnalytical and preparative HPLC separations were performed by using stainless-steel Phenomenex Luna phenyl-hexyl (250 x 4.6 mm and 250 x 22 mm, 5 and 10 mm particle size, respectively) and Phenomenex Luna C-18 (250 x 4.6 mm and 250 x 22 mm, 5 and 10 mm particle size, respectively). Mobile phases for chromatography were prepared from HPLC grade solvents. Methanol and acetonitrile were obtained from J.T. Baker (Phillipsburg, NJ, USA) and Tedia (Fairfield, OH, USA), respectively. Water was purified in-house with a Millipore Milli-Q system (Billerica, MA, USA). The analytical HPLC separations were carried out using a Shimadzu (Kyoto, Japan) LC-10Ai pump system, a Shimadzu SIL-10Ai aut...

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New compounds from avocado pear

Cited by 74 publications

References 5 publications

Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana

Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana

Antioxidant Properties of Selected African Vegetables, Fruits and Mushrooms: A Review

Aromatic compounds from three Brazilian Lauraceae species

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