New classification for probe-based confocal laser endomicroscopy in the colon

Kuiper, Teaco; Broek, Frank J.C. van den; Eeden, Susanne van; Wallace, Michael B.; Buchner, Anna M.; Meining, Alexander; Hee, K. van; Fockens, Paul; Dekker, Evelien

doi:10.1055/s-0030-1256767

Cited by 39 publications

(27 citation statements)

References 26 publications

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“…In the second one, instead, we showed the switch from the inflamed to neoplastic mucosa in a patient with chronic ulcerative colitis (CUC) [5]. We confirmed previously reported data, according to Kuiper's work [44], in which they also proposed a new pCLE colon classification, highlighting the high level of accuracy of pCLE in identifying colonic intraepithelial neoplasia. Furthermore, we demonstrated the clinical applicability and predictive power of pCLE also in a group of aberrant colonic crypt foci (ACF) collected during laser confocal endomicroscopy, through the concordance between endoscopic and histological features (rate of architectural alterations in the absence or presence of epithelial dysplasia).…”

Section: Discussionsupporting

confidence: 83%

Probe-Based Confocal Laser Endomicroscopy Evaluation of Colon Preneoplastic Lesions, with Particular Attention to the Aberrant Crypt Foci, and Comparative Assessment with Histological Features Obtained by Conventional Endoscopy

Mascolo

Staibano

Ilardi

et al. 2012

Gastroenterology Research and Practice

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The colorectal carcinoma represents one of the most common and aggressive malignancies, still characterized by an unacceptable mortality rate, mainly due to the high metastatic potential and to a late diagnosis. In the last years, the research community focused on the chance of improving the endoscopic screening to detect neoplastic lesions in a very early stage. Several studies proposed aberrant colonic crypt foci as the earliest recognizable step of transformation in colonic multiphase carcinogenesis. We previously demonstrated the clinical applicability and predictive power of probe-based confocal laser endoscopy (pCLE) in superficial colorectal neoplastic lesions and also characterized in vivo a case of dysplasia-associated lesional mass (DALM) in ulcerative colitis. Now, we aim to evaluate the accuracy of pCLE in the detection of ACF comparing in double-blind manner the microendoscopic and histopathological features resulting from colonic biopsy. By pCLE, we identified specific crypt architecture modifications associated with changes in cellular infiltration and vessels architecture, highlighting a good correspondence between pCLE features and histology.

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Section: Discussionsupporting

confidence: 83%

Probe-Based Confocal Laser Endomicroscopy Evaluation of Colon Preneoplastic Lesions, with Particular Attention to the Aberrant Crypt Foci, and Comparative Assessment with Histological Features Obtained by Conventional Endoscopy

Mascolo

Staibano

Ilardi

et al. 2012

Gastroenterology Research and Practice

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“…Both techniques allow for the identification of cellular structures in vivo and the possibility of optical biopsies but will require intensive work and computer support before clinical application. While CLM is preferentially applied in flexible endoscopy to differentiate between benign and malignant alterations [59,60], OCT is currently a highly contributing imaging modality in ophthalmology [60]. However, in surgery, the need for an in-vivo applicable near microscopic imaging modality also exists, and we already demonstrated that the differentiation between benign and malignant tissue is possible in that way ( fig.…”

Section: Optical Methodsmentioning

confidence: 96%

Enhanced Visualization: From Intraoperative Tissue Differentiation to Augmented Reality

et al. 2018

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Background: Optimal visualization of the operative field and methods that additionally provide supportive optical information form the basis for target-directed and successful surgery. This article strives to give an overview of current enhanced visualization techniques in visceral surgery and to highlight future developments. Methods: The article was written as a comprehensive review on this topic and is based on a MEDLINE search and ongoing research from our own group and from other working groups. Results: Various techniques for enhanced visualization are described comprising augmented reality, unspecific and targeted staining methods, and optical modalities such as narrow-band imaging. All facilitate our surgical performance; however, due to missing randomized controlled studies for most of the innovations reported on, the available evidence is low. Conclusion: Many new visualization technologies are emerging with the aim to improve our perception of the surgical field leading to less invasive, target-oriented, and elegant treatment forms that are of significant benefit to our patients.

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“…Such visualization of nuclei was also described with cresyl violet in a proof-of-principle study that combined chromoendoscopy and fluorescence imaging with a single dye [15]. A classification system for pCLE has just been published and will undergo further evaluation [47]. A further study compared pCLE for prediction of histology of colonic lesions with virtual chromoendoscopy techniques (NBI, FICE) and found a higher sensitivity for pCLE with similar specificity in classification of colorectal polyps [48].…”

Section: Endomicroscopy For Colonic Neoplasiamentioning

confidence: 99%

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Goetz

2012

ISRN Pathology

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Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist's armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows "smart," targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.

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New classification for probe-based confocal laser endomicroscopy in the colon

Cited by 39 publications

References 26 publications

Probe-Based Confocal Laser Endomicroscopy Evaluation of Colon Preneoplastic Lesions, with Particular Attention to the Aberrant Crypt Foci, and Comparative Assessment with Histological Features Obtained by Conventional Endoscopy

Probe-Based Confocal Laser Endomicroscopy Evaluation of Colon Preneoplastic Lesions, with Particular Attention to the Aberrant Crypt Foci, and Comparative Assessment with Histological Features Obtained by Conventional Endoscopy

Enhanced Visualization: From Intraoperative Tissue Differentiation to Augmented Reality

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

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