New calcium phosphate cements based on tricalcium phosphate

Komlev, V. S.; Фадеева, И. В.; Гурин, А. Н.; Shvorneva, L. I.; Bakunova, N. V.; Баринов, С. М.

doi:10.1134/s0012500811030098

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…HNTs include: poly(butylene succinate) [44], polyamide [12,45], styrene-butadiene [46], epoxy [47], poly(methyl-methacrylate) [48], and chitosan [43]. In our case, we speculate that HNTs distribution the CPC cement fills voids resulting in the increase of mechanical strength by preventing crack propagation.…”

Section: Flexural Strengthmentioning

confidence: 68%

“…CPCs have many advantages over PMMA cement. Low shrinkage, durable, dense or porous (depending on the site of injury), and formability (ability to fill cavities of complex configurations) are additional positive qualities of CPCs [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…HNTs have been used to increase surface area, impart high surface reactivity, and improve mechanical strength with a relatively low cost [32,34]. To achieve an increase in the toughness, mechanical strength, and thermal stability, HNTs have incorporated into a variety of polymers and examples include: poly(methyl-methacrylate) [35], poly(butylene succinate) [38], polyamide [12,39], styrene-butadiene [40], epoxy [41], and chitosan [42]. In two previous studies using electrospinning, HNTs were used to enhance the polymer material properties including biological, chemical, mechanical, and thermal properties (see Kamble et al, (2012) for a more detailed review) [34].…”

Section: Introductionmentioning

confidence: 99%

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Calcium Phosphate/Clay Nanotube Bone Cement with Enhanced Mechanical Properties and Sustained Drug Release

Jammalamadaka¹,

Tappa²,

Mills³

2018

Current Topics in the Utilization of Clay in Industrial and Medical Applications

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Calcium phosphate cement (CPC) has limited use in bone repair due to their poor mechanical properties. Halloysite nanotubes (HNTs) are clay tubes with an aluminosilicate composition. The physicochemical properties, cytocompatibility, and cellular response to the CPC/HNT composites were assayed. Compression strength, FTIR analysis, protein synthesis, and mineralization were assessed. The cumulative data show that composites of tricalcium phosphate (TCP), anhydrous calcium diphosphate (DCPA) as the solid phase agent, and 10% chitosan lactate solution as the setting liquid produced cement with sustained release properties without loss of material strength. The composite also showed enhanced material properties (adhesiveness, surface roughness, and increased strength). Cellular assays confirm its osteoconductive and osteoinductive nature. CPCs, loaded with gentamicin-and neomycin-doped HNTs, showed sustained antibacterial release and marked zone of growth inhibition. CPCs fabricated with drugdoped HNTs offer a means for inducing bone growth at the site of implantation while controlling infection. This treatment modality should hasten patient healing time and enhance restoration of function. The increase in materials properties suggests that this CPC may be clinically applied to repair injuries in load-bearing bones.

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