New bone-generative effect of Salvia officinalis L. in the expanded midpalatal suture

Kayalar, Emre; Göğer, Fatih; Deynek, Gul Tas; Tok, Olgu Enis; Küçük, Sevim

doi:10.1007/s00056-021-00366-3

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…However, the high relapse rate due to insufficient bone formation/mineralization remains a prime concern. To minimize relapse, various interventions have been used in animal models to augment bone formation, such as treatment with parathyroid hormone, 14 Salvia officinalis L. extracts, 15 and salvianolic acid B. 16 These biological factors and drugs should stimulate bone formation in MPS subjected to RME.…”

Section: Discussionmentioning

confidence: 99%

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

et al. 2023

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Objectives The mid-palatal expansion technique is commonly used to correct maxillary constriction in dental clinics. However, there is a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investigate whether signal transducer and activator of transcription 3 (STAT3) activation contributes to osteoblast-mediated bone formation during palatal expansion and relapse. Methodology In total, 30 male Wistar rats were randomly allocated into Ctrl (control), E (expansion only), and E+Stattic (expansion plus STAT3-inhibitor, Stattic) groups. Micro-computed tomography, micromorphology staining, and immunohistochemistry of the mid-palatal suture were performed on days 7 and 14. In vitro cyclic tensile stress (10% magnitude, 0.5 Hz frequency, and 24 h duration) was applied to rat primary osteoblasts and Stattic was administered for STAT3 inhibition. The role of STAT3 in mechanical loading-induced osteoblasts was confirmed by alkaline phosphatase (ALP), alizarin red staining, and western blots. Results The E group showed greater arch width than the E+Stattic group after expansion. The differences between the two groups remained significant after relapse. We found active bone formation in the E group with increased expression of ALP, COL-I, and Runx2, although the expression of osteogenesis-related factors was downregulated in the E+stattic group. After STAT3 inhibition, expansive force-induced bone resorption was attenuated, as TRAP staining demonstrated. Furthermore, the administration of Stattic in vitro partially suppressed tensile stress-enhanced osteogenic markers in osteoblasts. Conclusions STAT3 inactivation reduced osteoblast-mediated bone formation during palatal expansion and post-expansion relapse, thus it may be a potential therapeutic target to treat force-induced bone formation.

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Section: Discussionmentioning

confidence: 99%

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

et al. 2023

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New Perspectives about Relevant Natural Compounds for Current Dentistry Research

Dinu,

Dumitrel,

Buzatu

et al. 2024

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Natural compounds have been used since the earliest civilizations and remain, to this day, a safer alternative for treating various dental problems. These present antimicrobial, anti-inflammatory, antioxidant, analgesic, and antimutagenic effects, making them useful in the prophylactic and curative treatment of various oral diseases such as infections, gingivitis, periodontitis, and even cancer. Due to the high incidence of unpleasant adverse reactions to synthetic compounds, natural products tend to gradually replace conventional treatment, as they can be just as potent and cause fewer, milder adverse effects. Researchers use several methods to measure the effectiveness and safety profile of these compounds, and employing standard techniques also contributes to progress across all medical disciplines.

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New bone-generative effect of Salvia officinalis L. in the expanded midpalatal suture

Cited by 2 publications

References 46 publications

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

New Perspectives about Relevant Natural Compounds for Current Dentistry Research

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