New biodegradable nanoparticles-in-nanofibers based membranes for guided periodontal tissue and bone regeneration with enhanced antibacterial activity

Abdelaziz, Dina; Hefnawy, Amr; Al-Wakeel, Essam El Saeid; El-Fallal, Abeer; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.jare.2020.06.014

Cited by 98 publications

(95 citation statements)

References 95 publications

(99 reference statements)

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“…Such a result might be due to TSNP stacking (as observed in SEM images), which reduced the mobility of the polymer chains. A similar outcome was also reported by Abdelaziz et al (2020) as a result of adding hydroxyapatite nanoparticles to PCL composites [54].…”

Section: Mechanical Propertiessupporting

confidence: 89%

Antimicrobial Active Bioplastics Using Triangular Silver Nanoplate Integrated Polycaprolactone and Polylactic Acid Films

et al. 2021

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An innovative antimicrobial technology for plastic surfaces is presented. We report the synthesis and scale-up of triangular silver nanoplates (TSNPs) and their integration into polycaprolactone (PCL) and polylactic acid (PLA) polymers through a solvent-casting technique. The TSNPs have a high geometric aspect ratio and strong local surface plasmon resonance (LSPR) response, which provides an effective tool for monitoring their integrity during processing and integration with the biodegradable plastics. An aqueous-based seed-mediated chemical method was used to synthesize the TSNPs, and characterisation was carried out using TEM and UV (Ultraviolet)-VIS (Visible) spectroscopy to measure LSPR profiles. The UV-VIS spectra of silver seeds and TSNPs exhibited characteristic peaks at 395 and 600 nm respectively. Synthesized TSNPs were coated with thiol-terminated polyethylene glycol (SH-PEG) and transferred into chloroform in order to effect compatibility with PCL and PLA. TSNP/PCL and TSNP/PLA composite films were prepared by solvent casting. The morphological structure, thermal, mechanical, and antimicrobial properties of the TSNP-incorporated composite films were evaluated. Results showed the TSNP-treated films had a rougher surface than the bare films. Insignificant changes in the thermal properties of TSNP-treated films compared to bare ones were also observed, which indicated the thermal stability of the composite films. The tensile strength and antimicrobial properties of the composite films were increased after TSNP incorporation. TSNP/PCL and TSNP/PLA films exhibited improved antimicrobial activity against Escherichia coli and Staphylococcus aureus with antimicrobial effect (AE) values ranging between 0.10 and 0.35. The obtained results and demonstrated TSNP production scalability validate the TSNP treated PCL and PLA films as a composite material with desirable antimicrobial effect for wide-ranging surface applications.

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Section: Mechanical Propertiessupporting

confidence: 89%

Antimicrobial Active Bioplastics Using Triangular Silver Nanoplate Integrated Polycaprolactone and Polylactic Acid Films

et al. 2021

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“… [ 52 ] Silver nanoparticles Electrospinning nanofibrous with HA & silver nanoparticles N/A Initial material characteristics, release profile, and antimicrobial activity 32 days Improved bone regeneration activity; silver nanoparticles enhanced antibacterial effect. [ 47 ] Doxycycline & simvastatin Core-Shell poly-(D, l -Lactide- co -Glycolide)-chitosan Nanospheres IL-1β, MMP-8, VEGF Initial material characteristics, release profile, antibacterial examination, gene expression analysis, and in vivo periodontal healing evaluation 28 days Scaffold constantly released simvastatin and doxycycline and significantly inhibited P. gingivalis and S. sanguinis ; down-regulated IL-1β & MMP-8, up-regulated VEGF, and decreased bone loss in rat model. [ 50 ] nMgO Biodegradable multifunctional nanofibrous membrane N/A Initial material characteristics, antibacterial effects, osteogenesis evaluation, and in vivo periodontal healing evaluation 14 days in vitro ; 6 weeks in vivo nMgO incorporated membranes enhanced osteogenic property & the antibacterial effect against E. coli and S. aureus ; enhanced periodontal regeneration in rat model.…”

Section: Purpose Of Use Of Biomaterials Scaffolds For Periodontal Regementioning

confidence: 99%

“…Silver and magnesium (Mg) are another example of anti-microbial components. Abdelaziz et al reported that electrospun nanofibers containing silver nanoparticles had antibacterial effects over 32 days [ 47 ]. Liu et al reported that magnesium oxide (MgO)-conjugated nanofibrous membrane showed antibacterial activities to E. coli and S. aureus in a dose-dependent manner and showed promising in vivo efficacy in periodontal regeneration in rats [ 48 ].…”

Section: Purpose Of Use Of Biomaterials Scaffolds For Periodontal Regementioning

confidence: 99%

The recent advances in scaffolds for integrated periodontal regeneration

Woo

Cho

Tarafder

et al. 2021

Bioactive Materials

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The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Recently, various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal tissues. From a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium, technologies for scaffold fabrication have emerged in last years. This review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in vivo . Pros and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed, including future perspectives.

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“…Biodegradable electrospun membranes of poly(caprolactone) (PCL) or polylactide/cellulose acetate (PLA/CA) embedded with nano-HAp and AgNPs promoted the formation of bone-like apatite. The nanofibrous composites exhibited prolonged bactericidal effects, being proposed as suitable materials for orthodontic applications [ 322 ]. Liu et al, reported the successful fabrication of nanofibrous materials based on PLA/HAp nanowires modified with polydopamine membrane and coated with polypyrrole-stabilized AgNPs.…”

Section: Silver Nanoparticles For Tissue Engineeringmentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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New biodegradable nanoparticles-in-nanofibers based membranes for guided periodontal tissue and bone regeneration with enhanced antibacterial activity

Abstract: Graphical abstract

Cited by 98 publications

References 95 publications

Antimicrobial Active Bioplastics Using Triangular Silver Nanoplate Integrated Polycaprolactone and Polylactic Acid Films

Antimicrobial Active Bioplastics Using Triangular Silver Nanoplate Integrated Polycaprolactone and Polylactic Acid Films

The recent advances in scaffolds for integrated periodontal regeneration

An Updated Review on Silver Nanoparticles in Biomedicine

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