New benzoquinone pigments from the hydnoid fungus Sarcodontia setosa and their biosynthetic relationship

Abstract

Chemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivativessetosic acid (1) and 7,8dehydrohomosarcodontic acid (2) along with three known benzoquinone pigmentssarcodontic acid (3), 4,5-dehydrosarcodontic acid (4) and dihydrosarcodontic acid (5). The structures were elucidated using spectroscopic methods (UV, NMR, HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial activity screening of 2 compounds 1-5 against ESKAPE bacterial strains in vitro with zones of inhibition was performed and MIC values were established for the most active compounds (3 and 5).

The Conservation and Study of Macromycetes in the Komarov Botanical Institute Basidiomycetes Culture Collection—Their Taxonomical Diversity and Biotechnological Prospects

“…Screening tests of the antibacterial activity of these compounds against so-called ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) bacterial strains were carried out in vitro, and the biosynthetic relationships of the obtained compounds were discussed. K. pneumoniae, S. aureus, and A. baumannii were found to be most sensitive to compounds from S. setosa [115]. The investigation of the polypore fungus F. hepatica LE-BIN 3801 revealed four new polyacetylenic fatty acid derivatives-isocinnatriacetin, isocinnatriacetin A, cinnatriacetin C, and ethylcinnatriacetin A.…”