New approaches to diagnostics and treatment of cholangiocellular cancer based on photonics methods

Yakovlev, Dmitry; Farrakhova, Dina; Shiryaev, Artem; Efendiev, Kanamat; Loschenov, M. V.; Amirkhanova, Liana M.; Kornev, D.O.; Levkin, V.V.; Reshetov, Igor V.; Loschenov, Victor B.

doi:10.1007/s12200-020-1093-0

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…It is known that in the process of photochemical reaction there is a decrease in the concentration of PS, which is clinically expressed in photobleaching [28]. There are many works in the literature indicating the necessity to evaluate photobleaching in the PDT process for the purpose of personalized control [29][30][31][32]. Achieving a photobleaching of 50% or more positively influences treatment outcomes [33].…”

Section: Wound Healing With Pdtmentioning

confidence: 99%

Photodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora

Shiryaev,

Ivankov,

Voitova

et al. 2024

Photonics

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Background: Difficulties in the treatment of purulent wounds are caused by bacterial biofilms, which results in decontamination limitations. Infected wounds are not sufficiently susceptible to existing antibiotics, necessitating the search for alternative approaches to reduce the concentration of pathogenic microflora. Methods: This study describes an approach to the effective treatment of wounds by photodynamic inactivation or therapy (PDI/PDT) of antibiotic-resistant microflora under fluorescence control. For this purpose, laser and LED light (660–680 nm) and different groups of photosensitizers (PS) (1% solutions of methylene blue, aluminum phthalocyanine, chlorine e6 and nanocomposites containing these groups of PS) were used. The study included 90 patients with various wounds. Some patients were subjected to fluorescence diagnosis by laser spectral analysis before the PDT. Results: Positive results were achieved in 76 patients (84%, p < 0.05). After the first PDT session, a decrease in the concentration of microflora was noticeable. By the third and seventh days, a significant to complete inactivation of bacteria was obtained. In all patients who were photo-diagnosed before PDT, a significant PS concentration decrease of more than 75% after PDT was obtained. Conclusion: PDT is an effective method for the inactivation of antibiotic-resistant pathogens, including in long non-healing wounds, contributing also to early tissue regeneration.

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Section: Wound Healing With Pdtmentioning

confidence: 99%

Photodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora

Shiryaev,

Ivankov,

Voitova

et al. 2024

Photonics

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“…Passive microspheres made of polymethyl methacrylate (PMMA), polymer, borosilicate, Ba-Ti oxide, polystyrene, silica, barium titanate, and so on, can be embedded into the mentioned optical fibers to construct in-fiber resonators, and have been successfully applied in applications including temperature [ 37 ], refractive index [ 39 ], and displacement sensing [ 40 ]. Besides, dye and rare-earth ion can be doped into the microsphere material, thereby emitting fluorescence [ 41 – 45 ]. As the counterpart of passive microspheres, active microspheres are of great interest for in-fiber resonators because they provide the possibilities of remote excitation and breaking the limitations of passive microspheres.…”

Section: Introductionmentioning

confidence: 99%

Recent progress of in-fiber WGM microsphere resonator

Yang

Zhang

2023

Front. Optoelectron.

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In-fiber whispering gallery mode (WGM) microsphere resonators have received remarkable attention due to the superiorities of compact structure, high stability and self-alignment. As an in-fiber structure, WGM microsphere resonators have been demonstrated in various applications, such as sensors, filters and lasers, which have significant impacts on modern optics. Herein, we review recent progress of in-fiber WGM microsphere resonators, which involve fibers of diverse structures and microspheres of different materials. First, a brief introduction is given to in-fiber WGM microsphere resonators, from structures to applications. Then, we focus on recent progresses in this field, including in-fiber couplers based on conventional fibers, capillaries and micro-structure hollow fibers, and passive/active microspheres. Finally, future developments of the in-fiber WGM microsphere resonators are envisioned. Graphical Abstract

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“…Through the continuous development and research of new medical technologies, fluorescence diagnostics (FD) and photodynamic therapy (PDT) have shown potential in the diagnosis and treatment of CCC [7,8]. Chlorin e6 is a well-known photosensitizer that is widely used for various malignant neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Capabilities of Spectroscopic and Quantitative Video Analysis of Fluorescence for the Diagnosis and Photodynamic Therapy Control of Cholangiocellular Cancer

et al. 2022

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Cholangiocellular cancer (CCC) is a malignant neoplasm of the hepatobiliary system that is difficult to diagnose and treat. Currently, the most effective treatment of CCC is demonstrated under the control by fluorescent diagnosis. Photodynamic therapy (PDT) has also shown good results in the treatment of this disease, and fluorescence analysis of the photosensitizer is a good approach to control PDT. This article presents the results of a comparison of spectroscopic and quantitative video-fluorescent analysis of chlorin e6 photosensitizer fluorescence in vivo during cholangiocellular cancer surgery. Spectroscopic analysis provides accurate information about the concentration of the photosensitizer in the tumor, while the video-fluorescence method is convenient for visualizing tumor margins. A direct correlation is shown between these two methods when comparing the fluorescence signals before and after PDT. The applied paired Student’s t-test shows a significant difference between fluorescence signal before and after PDT in both diagnostic methods. In this regard, video-fluorescence navigation is not inferior in accuracy, sensitivity, or efficiency to spectroscopic methods.

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New approaches to diagnostics and treatment of cholangiocellular cancer based on photonics methods

Cited by 8 publications

References 18 publications

Photodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora

Photodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora

Recent progress of in-fiber WGM microsphere resonator

Comparison of the Capabilities of Spectroscopic and Quantitative Video Analysis of Fluorescence for the Diagnosis and Photodynamic Therapy Control of Cholangiocellular Cancer

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