New approaches for integrated and cost-effective malaria vector control

Dambach, Peter

doi:10.29245/2572-9411/2018/1.1144

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…Although malaria control programs that are limited to performing larviciding in the public space, such as the one presented here, can provide major reductions in Anopheles mosquito abundance, they often lack the ability to sufficiently reduce other disease transmitting mosquitoes, such as various species of Culex and Aedes. These develop in breeding sites that are typically found in private compounds [25]. Whereas our study targeting Anopheles mosquitoes in public places showed a reduction on Aedes but not on Culex, it raises the question about the possibility of extending larviciding to private compounds.…”

Section: Plos Onecontrasting

confidence: 56%

Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso

et al. 2021

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Objectives To evaluate the impact of anti-malaria biological larviciding with Bacillus thuringiensis israelensis on non-primary target mosquito species in a rural African setting. Methods A total of 127 villages were distributed in three study arms, each with different larviciding options in public spaces: i) no treatment, ii) full or iii) guided intervention. Geographically close villages were grouped in clusters to avoid contamination between treated and untreated villages. Adult mosquitoes were captured in light traps inside and outside houses during the rainy seasons of a baseline and an intervention year. After enumeration, a negative binomial regression was used to determine the reductions achieved in the different mosquito species through larviciding. Results Malaria larviciding interventions showed only limited or no impact against Culex mosquitoes; by contrast, reductions of up to 34% were achieved against Aedes when all detected breeding sites were treated. Culex mosquitoes were captured in high abundance in semi-urban settings while more Aedes were found in rural villages. Conclusions Future malaria larviciding programs should consider expanding onto the breeding habitats of other disease vectors, such as Aedes and Culex and evaluate their potential impact. Since the major cost components of such interventions are labor and transport, other disease vectors could be targeted at little additional cost.

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Section: Plos Onecontrasting

confidence: 56%

Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso

et al. 2021

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“…Although in the context of malaria, other mosquito species have less importance, they do play a role when it comes to nuisance and vector borne diseases such as lymphatic filariasis, yellow fever, dengue, and Zika. Although malaria control programs that only perform larviciding in the public space, as the one presented here, can provide major reductions in Anopheles mosquito abundance, they lack the ability to sufficiently reduce other disease transmitting mosquitoes such as Culex andAedes that develop in breeding sites that are typically found in private compounds(34). While we expect only limited additional relief in Anopheles abundance when extending spraying activities to private compounds, it might show a strong impact on the numbers of Culex and Aedes mosquitoes.…”

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confidence: 79%

Effect of biological larviciding with Bacillus thuringiensis israelensis for malaria control on non-target vector mosquito species in rural Burkina Faso – A cluster randomized trial

Dambach

Bärnighausen

Yadouléton³

et al. 2019

Preprint

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Background: Biological larviciding is an additional tool that can help address the current dilemma in malaria control, namely vector resistances to pyrethroids and shifting of biting activity to times when people are not protected. Although malaria interventions primarily target Anopheles mosquitoes, there might be an impact on populations of other mosquito genera that share the same breeding sites. In this study we research to what extent Culex and Aedes mosquitoes, the primary vectors of numerous zoonotic diseases, are affected by larviciding interventions against malaria mosquitoes. Methods: We researched the impact of different larviciding choices with Bacillus thuringiensis israelensis on non-target mosquitoes in 127 rural villages and a semi-urban town in a health district in Northwestern Burkina Faso. All villages were distributed into a total of three study arms with different larviciding choices: full, selective and untreated control. Geographically close villages were distributed into clusters to avoid contamination between treated and untreated villages. Adult mosquitoes were captured in light traps inside and outside houses during the rainy seasons of a baseline and an intervention year. A negative binomial regression was used to determine the reductions achieved through larviciding among different mosquito genera.Results: Larviciding interventions against malaria showed only limited or no impact against Culex mosquitoes, while against Aedes, reductions of up to 34% were achieved when all detected breeding sites in the public space were treated. While the semi-urban setting showed high abundance of Culex, in the rural villages we captured more Aedes. Conclusions: Future larviciding programs should be evaluated for including the treatment of Aedes and Culex breeding habitats. Since the major cost components of such programs are labor and transport, other disease vectors could be targeted at little additional cost.

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“…This is important because it is likely to impact people’s perception on the success of larviciding interventions, since they cannot distinguish different mosquito genera and assess their potential risk for malaria transmission. Furthermore, this extended larviciding would allow for a more synergistic targeting of vectors of other mosquito-borne diseases, such as dengue, Zika, yellow fever and filariasis [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Community acceptance of environmental larviciding against malaria with Bacillus thuringiensis israelensis in rural Burkina Faso – A knowledge, attitudes and practices study

Dambach

Traoré

Sawadogo

et al. 2021

Global Health Action

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Background Malaria control is based on early treatment of cases and on vector control. The current measures for malaria vector control in Africa are mainly based on long-lasting insecticidal nets (LLINs) and to a much smaller extent on indoor residual spraying (IRS). While bed net use is widely distributed and its role is intensively researched, Bti-based larviciding is a relatively novel tool in Africa. In this study, we analyze the perception and acceptability of Bti-based larval source management under different larviciding scenarios that were performed in a health district in Burkina Faso. Objective To research people’s perception and acceptance regarding biological larviciding interventions against malaria in their communities. Methods A cross-sectional study was undertaken using a total of 634 administered questionnaires. Data were collected in a total of 36 rural villages and in seven town quarters of the semi-urban town of Nouna. Results Respondents had basic to good knowledge regarding malaria transmission and how to protect oneself against it. More than 90% reported sleeping under a bed net, while other measures such as mosquito coils and insecticides were only used by a minority. The majority of community members reported high perceived reductions in mosquito abundance and the number of malaria episodes. There was a high willingness to contribute financially to larviciding interventions among interviewees. Conclusions This study showed that biological larviciding interventions are welcomed by the population that they are regarded as an effective and safe means to reduce mosquito abundance and malaria transmission. A routine implementation would, despite low intervention costs, require community ownership and contribution.

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New approaches for integrated and cost-effective malaria vector control

Cited by 7 publications

References 34 publications

Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso

Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso

Effect of biological larviciding with Bacillus thuringiensis israelensis for malaria control on non-target vector mosquito species in rural Burkina Faso – A cluster randomized trial

Community acceptance of environmental larviciding against malaria with Bacillus thuringiensis israelensis in rural Burkina Faso – A knowledge, attitudes and practices study

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