New Antimicrobial Cyclopentenones from Nigrospora sphaerica ZMT05, a Fungus Derived from Oxya chinensis Thunber

Abstract

Six new cyclopentenone derivatives (+)-nigrosporione A (+)-1, (-)-nigrosporione A (-)-1, nigrosporione B (2), nigrosporione C (3), (+)-nigrosporione D (+)-4, and (-)-nigrosporione D (-)-4 were isolated from an endophytic fungus Nigrospora sphaerica ZMT05, collected from the rice grasshopper ( Oxya chinensis Thunberg), which is an insect pest in rice and which is also used as a food for people in some countries. Their planar and spatial structures were determined by spectroscopic analyses and eletronic circular dichroism (ECD) calculations. Compounds (+)-1, (-)-1, and 2 inhibited the plant pathogens Fusarium oxysporum, Colletotrichum musae, Penicillium italicum, and Fusarium graminearum, compounds 3 and (-)-4 inhibited F. oxysporum, C. musae, and P. italicum, and compound (+)-4 inhibited F. oxysporum, C. musae, and F. graminearum, showing antifungal activities stronger than triadimefon. Additionally, compounds (+)-1, (-)-1, 2, and 3 displayed moderate antibacterial activities against Staphyloccocus aureus and Escherichia coli.

The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002

“…The antimicrobial activities against five bacteria ( S. aureus (ATCC 6538), B. subtilis (ATCC 6633), E. coli (ATCC 8739), P. aeruginosa (ATCC 9027), and S. enteritidis (ATCC 14028)) along with three phytopathogenic fungi ( P. italicum (BNCC 118157), C. musae (BNCC 226680), and G. zeae (BNCC 116158)) were evaluated on 96-well microtiter plates using a modification of the broth microdilution method [37,38]. The microbial test strain was incubated, and the microbial strain suspension was diluted to a seeding density of 5 × 10 5 cfu compared to the MacFarland standard.…”

Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29

“…Three fungi including F. oxysporum , P. italicum , and F. graminearum used for bioassay were acquired from the College of Agriculture, South China Agricultural University. The antifungal effects were examined by the two-fold broth dilution method, as previously reported [17].…”

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

“…Conformational analyses and density functional theory (DFT) calculations were used to generate and optimize the conformers with energy. The ECD calculations were performed as the method descripted in a reported article [ 24 ].…”