New and Unexpected Roles for Primary Cilia in Coordinating Response to Mechanical Load in Articular and Growth Plate Cartilages

Serra, Rosa

doi:10.1002/jbmr.4557

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…85 ATP activates the cytosolic Ca 2+ signaling cascade. It is also documented that the primary cilia act as “mechano-dampeners” in the cartilage, 86 which means primary cilia are more of buffer mediators to protect AC.…”

Section: Primary Cilia Mediated the Mechanotransduction Of Chondrocytesmentioning

confidence: 99%

Primary cilium–mediated mechanotransduction in cartilage chondrocytes

Zhang,

Tawiah,

et al. 2023

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the degradation of articular cartilage and an abnormal mechanical microenvironment. Mechanical stimuli, including compression, shear stress, stretching strain, osmotic challenge, and the physical properties of the matrix microenvironment, play pivotal roles in the tissue homeostasis of articular cartilage. The primary cilium, as a mechanosensory and chemosensory organelle, is important for detecting and transmitting both mechanical and biochemical signals in chondrocytes within the matrix microenvironment. Growing evidence indicates that primary cilia are critical for chondrocytes signaling transduction and the matrix homeostasis of articular cartilage. Furthermore, the ability of primary cilium to regulate cellular signaling is dynamic and dependent on the cellular matrix microenvironment. In the current review, we aim to elucidate the key mechanisms by which primary cilia mediate chondrocytes sensing and responding to the matrix mechanical microenvironment. This might have potential therapeutic applications in injuries and OA-associated degeneration of articular cartilage.

show abstract

Section: Primary Cilia Mediated the Mechanotransduction Of Chondrocytesmentioning

confidence: 99%