New and personalized ventilatory strategies in patients with COVID-19

Abstract

Coronavirus disease (COVID-19) is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus and may lead to severe respiratory failure and the need for mechanical ventilation (MV). At hospital admission, patients can present with severe hypoxemia and dyspnea requiring increasingly aggressive MV strategies according to the clinical severity: noninvasive respiratory support (NRS), MV, and the use of rescue strategies such as extracorporeal membrane oxygenation (ECMO). Among NRS strategies, new tools have been adopted for critically ill patients, with advantages and disadvantages that need to be further elucidated. Advances in the field of lung imaging have allowed better understanding of the disease, not only the pathophysiology of COVID-19 but also the consequences of ventilatory strategies. In cases of refractory hypoxemia, the use of ECMO has been advocated and knowledge on handling and how to personalize strategies have increased during the pandemic. The aims of the present review are to: (1) discuss the evidence on different devices and strategies under NRS; (2) discuss new and personalized management under MV based on the pathophysiology of COVID-19; and (3) contextualize the use of rescue strategies such as ECMO in critically ill patients with COVID-19.

Evolução Clínica e Fatores Prognósticos de Pacientes Oncológicos com Covid-19 em Ventilação Mecânica

“…Outra limitação do estudo foi não conseguir estratificar os pacientes quanto aos fenótipos de SDRA estabelecidos recentemente na literatura. A identificação de diferentes fenótipos no diagnóstico de SDRA foi uma das importantes modificações que ocorreram após a pandemia de covid-19, e que possibilita uma melhor estratificação de pacientes de modo a fornecer assistência ventilatória personalizada, com parâmetros dinâmicos que se adequem ao perfil de mecânica respiratória e às características clínicas individuais tanto na SDRA por covid-19 quanto por outras etiologias 12,42 .…”