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“…Compounds with g-butyrolactone-core (furanone) show diverse biological activities such as antitumor and anti-inflammatory activity [1][2][3]. It is reported that butalactin exhibits moderate antibacterial activity against Gram-positive bacteria [4].…”
Section: Discussionmentioning
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“…Compounds with g-butyrolactone-core (furanone) show diverse biological activities such as antitumor and anti-inflammatory activity [1][2][3]. It is reported that butalactin exhibits moderate antibacterial activity against Gram-positive bacteria [4].…”
Section: Discussionmentioning
“…There have been a lot of studies on the association between free radicals, oxidative stress and inflammation (Weber et al, 2005;Abreu et al, 2006;Pontiki et al, 2006). Instead of just looking at the action of drugs/herbs on pro-inflammatory cytokines or/and other inflammatory mediators, their free radical scavenging capacities should also be considered.…”
Section: Anti-inflammatory Effectsmentioning
“…The organic phase was washed with a NaCl saturated solution (5Â), dried over Na 2 SO 4 , filtered and evaporated. The residue was purified by flash chromatography on silica gel (eluting mixture from 100% CHCl 3 to 10% MeOH + 1% Et 3 N in CHCl 3 ) to obtain the title compound as a white solid (20 …”
Section: -((6-mentioning
“…Hydrazines 9a-g were prepared following described procedures [15][16][17][18] . Non-commercially available aldehydes 10a,b were prepared following reported procedures 19,20 . Piperazines 15,16 were prepared following described procedures 21,22 .…”
Section: Chemistrymentioning