Nevus Type in Dermoscopy Is Related to Skin Type in White Persons

Zalaudek, Iris; Argenziano, Giuseppe; Mordente, Ines; Moscarella, Elvira; Corona, Rosamaria; Sera, Francesco; Blum, Andreas; Cabo, Horacio; Stefani, Alessandro; Hofmann‐Wellenhof, Rainer; Johr, Robert H.; Langford, David; Malvehy, Josep; Kolm, Isabel; Sgambato, Anna; Puig, Susana; Soyer, H. Peter; Kerl, Helmut

doi:10.1001/archderm.143.3.351

Cited by 73 publications

(74 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the same time, Zalaudek et al [8] suggested that the red hair color phenotype of the MC1R gene is associated with ‘white' nevi and ‘red' melanomas. Finally, Zalaudek et al [9] found significant differences in the prevalent nevus pattern in the various skin type groups and Cohen-Solal et al [10] showed that crossing a transgenic mouse with several albino strains characterized by an inactive tyrosinase influenced the phenotype of the developed cutaneous melanoma, inducing mainly the amelanotic ones [9,10]. …”

Section: Discussionmentioning

confidence: 99%

Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series

Caldarola¹,

Fania²,

Fossati³

et al. 2013

Dermatology

View full text Add to dashboard Cite

Background: Although the majority of skin cancers in albino patients consists of squamous and basal cell carcinomas, malignant melanomas have also been described, albeit less frequently. Objective: The aim of our study was to evaluate melanocytic lesions in albino patients to look for any recurrent dermoscopic pattern. Methods: We enrolled 12 consecutive albino patients presenting to our department and examined each patient for the presence of melanocytic nevi with the unaided eye and then with dermoscopy. Melanocytic lesions with suspicious clinical or dermoscopic features were excised and histopathologically evaluated. Results: Analysis of the recorded images permitted us to find two main dermoscopic patterns in this group of patients. The first one was represented by a homogeneous light-brown yellowish pattern associated with comma-like and dotted vessels; the second one consisted of a classical brown reticular pattern frequently associated with central depigmentation and with comma-like vessels. Moreover, based on some atypical dermoscopic features, in 2 patients we excised 3 melanomas in situ (in the same patient) and a thick melanoma (3.2 mm). Conclusions: Dermoscopy may represent a useful tool for the evaluation of melanocytic lesions in albino patients, permitting an early diagnosis of melanoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series

Caldarola¹,

Fania²,

Fossati³

et al. 2013

Dermatology

View full text Add to dashboard Cite

show abstract

“…Nevi of skin types II and III are prone to be light to dark brown with multifocal pigmentation ( Figure 5). 44,45 …”

Section: Skin Type-related Nevus Patternmentioning

confidence: 99%

Using Dermoscopic Criteria and Patient-Related Factors for the Management of Pigmented Melanocytic Nevi

Zalaudek

Docimo

Argenziano³

2009

Arch Dermatol

Self Cite

100

View full text Add to dashboard Cite

Objective: To review recent dermoscopy studies that provide new insights into the evolution of nevi and their patterns of pigmentation as they contribute to the diagnosis of nevi and the management of pigmented melanocytic nevi. Data Sources: Data for this article were identified by searching the English and German literature by Medline and Journals@Ovid search for the period 1950 to January 2009. Study Selection: The following relevant terms were used: dermoscopy, dermatoscopy, epiluminescence microscopy (ELM), surface microscopy, digital dermoscopy, digital dermatoscopy, digital epiluminescence microscopy, digital surface microscopy, melanocytic skin lesion, nevi, and pigmented skin lesions. There were no exclusion criteria. Data Synthesis: The dermoscopic diagnosis of nevi relies on the following 4 criteria (each of which is characterized by 4 variables): (1) color (black, brown, gray, and blue); (2) pattern (globular, reticular, starburst, and homogeneous blue pattern); (3) pigment distribution (multifocal, central, eccentric, and uniform); and (4) special sites (face, acral areas, nail, and mucosa). In addition, the following 6 factors related to the patient might influence the pattern of pigmentation of the individual nevi: age, skin type, history of melanoma, UV exposure, pregnancy, and growth dynamics. Conclusions: The 4×4×6 “rule” may help clinicians remember the basic dermoscopic criteria of nevi and the patient-related factors influencing their patterns. Dermoscopy is a useful technique for diagnosing melanocytic nevi, but the clinician should take additional factors into consideration to optimize the management of cases of pigmented lesions.

show abstract

“…Fourth, although we performed histopathology or RCM in only four children, we exclude the possibility of eruptive Spitz nevi in our series, as nevi acquired over time the stereotypical clinical and dermoscopic features of a dermal nevus or Clark nevus with a peripheral rim of light brown pigmentation. The striking common clinical phenotype of children and the unusual appearance of nevi appear more than coincidentally and raise the question of a common underlying genetical background; thereby evidence suggests that a person's propensity to develop specific morphologic nevus subtypes is genetically determined with expression strongly influenced by the process of pigmentation; [6][7][8][9] While awaiting further insights in the underlying genetical background shared between our young patients, we like to conclude our observation with the goal to make clinicians aware of this event.I. Zalaudek, …”

mentioning

confidence: 99%

‘Eruptive’ amelanotic compound nevi in children with facial freckles and pale skin colour: more than an occasion?

Zalaudek

Moscarella

Sturm

et al. 2013

Acad Dermatol Venereol

View full text Add to dashboard Cite

'Eruptive' amelanotic compound nevi in children with facial freckles and pale skin colour: more than an occasion?Editor The term 'eruptive melanocytic nevi' refers to the sudden onset of multiple melanocytic nevi such as common, dysplastic, Spitz and blue nevi on previously unaffected skin. The development of eruptive melanocytic nevi has frequently been linked to systemic immune suppression, although it does not appear to represent a conditio sine qua non. [1][2][3] In this study, we report seven children with a common phentoype, who developed eruptive amelanotic melanocytic nevi and discuss whether this phenomenon is more than occasional.All seven children (six boys) were seen between 1995 and 2011 at dermatologic clinics in Italy, where most children have an average skin type of II and III. The mean age of the seven children was 8.1 years (range: 4-12 years) and all children had facial freckles (Fig. 1a) and a fair skin colour, although their hair and eye colour was variable. None of the children had general health problems. Only one child had a family history of maternal basal cell carcinoma.All children presented with numerous monomorphous, pink to skin coloured, dome-shaped, smooth, asymptomatic papules that developed within a few weeks (mean duration 2.4 weeks) (Fig. 1b,c), which were diagnosed as papular eruption, eruptive juvenile xanthogranulomas or Spitz nevi. Dermoscopy revealed skin coloured to brownish structureless areas with some enhancement of the pigmentation at the periphery, at times associated with loosely arranged dotted and short commashaped vessels (Fig. 1d).Histopathological examination was performed in two children, while two other children underwent examination with reflectance confocal microscopy (RCM). Both methods revealed a benign melanocytic compound nevus with keratotic epidermal changes (Fig 1e). JEADV Follow-up data ranged from 1 to 16 years (mean: 9 years). Nevus count remained basically stable over time. Most nevi acquired either the stereotypical appearance of a dermal nevus or developed a peripheral brown pigmentation (Fig. 2). None of the children developed melanoma or had other episodes of newly developing eruptive nevi.Our observation of an eruptive formation of amelanotic nevi in seven healthy, genetically unrelated children with a common clinical phenotype is novel and raise a number of questions about the frequency and significance of our findings.The true frequency of this event is currently unknown; however, given the unusual appearance of nevi, it is plausible that such a phenomenon is under-reported; in fact, neither parents nor clinicians though about amelanotic nevi in the affected children. Alternatively, alerted parents, prompted by a new developing lesion, may have simply recognized other lesions that actually have developed earlier.Our observation differs in several aspects from previously described eruptive nevi: First, nevus counts in our children were much lower compared with 'classical' cases. 4,5 Second, eruptive nevi are typically associated with events...

show abstract

Nevus Type in Dermoscopy Is Related to Skin Type in White Persons

Cited by 73 publications

References 18 publications

Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series

Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series

Using Dermoscopic Criteria and Patient-Related Factors for the Management of Pigmented Melanocytic Nevi

‘Eruptive’ amelanotic compound nevi in children with facial freckles and pale skin colour: more than an occasion?

Contact Info

Product

Resources

About