Nevus Lipomatosus Cutaneus Superficialis (Hoffman-Zurhelle)

Giant Nevus Lipomatosus Cutaneus Superficials: Case Report and Review of the Literature

“…It is usually present by the second or third decades of life, but lesions appearing in the fifth and sixth decades of life have been reported (2). There is no familial incidence (2) or sex predilection (2,4).…”

“…The patient had coalescent bilateral lesions that formed pendular masses leading to great deformity and discomfort. Differential diagnosis of NLCS includes several other entities: neurofibromatosis, focal dermal hypoplasia (4), connective tissue nevus (4,5), lipoma (4), epidermal nevus (4), juvenile elastoma (5), lipoblastomatosis (5), and Michelin tire syndrome (l); however, clinicopathologic correlation easily segregates these entities.…”

Nevus Lipomatosus Cutaneus Superficialis (Hoffmann‐Zurhelle)

“…Presence of comedones characterized by cystic dilation of the hair follicles and keratotic plugging at the surface of some nodular lesions have been reported by Lynch & Goltz (1958), Cramer (1960), Szodoray & Szondy (1961), Abel & Dougherty (1962), Kurihara et al (1967) and Wilson-Jones ct al. (1975).…”

Multiple yellowish plaques in cerebriform pattern on the right elbow

“…Clinical variants are of two types – classical (Hoffman–Zurhelle) and solitary 3 . The classical type, first described by Hoffman and Zurhelle, consists of multiple asymptomatic, non‐tender, soft, flesh‐colored or yellowish lesions that may coalesce to form plaque with smooth, wrinkled, peau d’orange‐type, or cerebriform surface with or without the presence of comedones and follicular orifices 4 …”

“…3 The classical type, first described by Hoffman and Zurhelle, consists of multiple asymptomatic, non-tender, soft, flesh-colored or yellowish lesions that may coalesce to form plaque with smooth, wrinkled, peau d'orange-type, or cerebriform surface with or without the presence of comedones and follicular orifices. 4 Lesions are usually unilateral with linear or zosteriform pattern, with predilection for the abdomen, back, buttocks, hips, upper posterior thigh and pelvic girdle. Atypical sites include the face, 5 pinna, 6 and neck.…”