Neutrophils Resembling L. E. Cells in Artificial Blisters

In‐vivo nuclear localisation of human antinuclear antibodies in mice with carbon tetrachloride‐ and thioacetamide‐induced hepatic necrosis

“…This observation, therefore, raises the possibility that a similar reaction may occur in human disease and that these auto-antibodies may possibly contribute to the development of lesions in SLE and the other connective-tissue diseases. This mechanism might explain the previous reports of in-vivo formation of both LE cells (Watson et al, 1951 ;Sickley et al, 1955;Perillie et al, 1960) and haematoxylin bodies (Klemperer et al, 1950) and also the observation that nuclear deposits of IgG are present in skin lesions of patients with SLE . The experiments also supplement the already considerable evidence that antinuclear antibodies are present in the renal lesions of SLE (Freedman and Markowitz, 19623;Koffler et al, 1967;Krishnan and Kaplan, 1967) as well as increasing the possibility that these antibodies may be present in some of the other IgG deposits found in this disease Dixon, 1957, 1958;Lange et al, 1966;.…”

The deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus.

“…Although skin lesions occur in 60-75% ofpatients with SLE (Tuffanelli, 1972), the role of skin reactivity to nuclear antigens has not been established. Some authors have demonstrated LE-cells in the skin (Perillie, Calabresi & Finch, i960;Rebuck & Berman, 1950;Watson, O'Leary & Hargraves 1951;Wilson, Abbott & Miller, 1961). Further, some investigators have been able to demonstrate the LE cell phenomenon at the site of intradermal injection of leukocytes or DNA (Ghosh, 1972;Ores & Mandel, 1970;Rebuck & Berman, 1950), while others have failed to do so (Richter & Apostoloff, 1970).…”