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Cited by 94 publications
(61 citation statements)
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“…Neutrophils were detected in the CD11b posi /Gr-1 high population, which is a commonly used population to detect neutrophils. 24,25,26 We first confirmed that peripheral blood could be clearly fractionated to CD11b posi /Gr-1 high neutrophils, CD11b posi /Gr-1 neg-int monocytes, and CD11b neg /Gr-1 neg lymphocyte populations ( Figure 3A). In uninjured spinal cord, few neutrophils were present in the spinal cord tissue, suggesting that in a normal physiological state the influx of neutrophils is strictly regulated by the bloodbrain barrier.…”
Section: Temporal Change In Neutrophil Infiltration and Quantitative mentioning
confidence: 55%
“…Neutrophils were detected in the CD11b posi /Gr-1 high population, which is a commonly used population to detect neutrophils. 24,25,26 We first confirmed that peripheral blood could be clearly fractionated to CD11b posi /Gr-1 high neutrophils, CD11b posi /Gr-1 neg-int monocytes, and CD11b neg /Gr-1 neg lymphocyte populations ( Figure 3A). In uninjured spinal cord, few neutrophils were present in the spinal cord tissue, suggesting that in a normal physiological state the influx of neutrophils is strictly regulated by the bloodbrain barrier.…”
Section: Temporal Change In Neutrophil Infiltration and Quantitative mentioning
confidence: 55%
“…56,79 Between days 3 and 5 after UV exposure, CD11b ϩ IL-10 -producing macrophages start to appear. 80 Macrophage phenotype can be altered by IL-33 81 suggesting that UV-induced IL-33 may also affect macrophage function, although further studies are required to determine whether this is the case. The significance of neutrophil homing to IL-33 producing dermal cells has only recently become apparent, when it was demonstrated that IL-33 enhances the expression of ST2 on neutrophils, allowing them to directly respond to IL-33 signals in tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Double-staining experiments ruled out that the IL-4 expression was induced in resident cutaneous cells, such as T cells, mast cells, or NK cells; all known to possess the capacity to synthesize IL-4 (18). For several reasons, we believe that the UVBinduced IL-4 ϩ cells are neutrophils: 1) neutrophils are able to produce IL-4 (19); 2) the IL-4 ϩ cells coexpress CD11b and CD15, but not CD36; 3) they have a multilobed nucleus; 4) IL-4 expression is associated with the neutrophil marker elastase, as indicated by serial section staining and distribution pattern; 5) neutrophils are well known to infiltrate human and murine skin after exposure to an erythemogenic dose of UVB or UVA (8,9,20,21); 6) the time course of infiltration of the IL-4 ϩ cells matches perfectly the infiltration kinetics of polymorphonuclear leukocytes upon UV irradiation, as reported by others (8,9,22). Although macrophages also express CD11b and infiltrate UVB-irradiated skin, they are improbable candidates for the IL-4 ϩ cells because of the presence of CD36 and the absence of CD15.…”
Section: Figure 6 Depletion Of Cd15mentioning
confidence: 99%