Neutrophilic Folliculitis and the Spectrum of Pyoderma Gangrenosum in Inflammatory Bowel Disease

Rühl, Anne; Ganz, Jodi; Bickston, Stephen J.

doi:10.1007/s10620-006-9361-4

Cited by 11 publications

(6 citation statements)

References 57 publications

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“…The differential diagnosis depends on the type and evolutionary stage of PPG. Generally, differential diagnoses include infectious diseases, malignancy, vasculitis and insect bites [18, 54]. A thorough review of history of the ulcer is usually helpful to rule out other courses and a careful gastrointestinal examination, such as colonoscopy or ileoscopy via stoma, will help to identify whether patients have underlying diseases, i.e.…”

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

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Diagnosis and management of parastomal pyoderma gangrenosum

Shen

2013

Gastroenterology Report

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Parastomal pyoderma gangrenosum (PPG) is an unusual neutrophilic dermatosis characterized by painful, necrotic ulcerations occurring in the area surrounding an abdominal stoma. It typically affects young to middle-aged adults, with a slight female predominance. The underlying etiology for PPG remains enigmatic but aberrant immune response to injury may play a pivotal role. The reported risk factors for the development of PPG include the presence of extra-intestinal manifestations, autoimmune disorders and obesity, along with local factors, such as the presence of parastomal hernia or pressure ulcer. PPG can develop at any time after the stoma construction. The histopathological features of PPG are not pathognomonic and its diagnosis is mainly based on clinical features. The management of PPG often requires a multidisciplinary approach, with a combination of local wound care and systemic medications.

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Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

“…Dapsone and minocycline are the most frequently prescribed agents to provide a steroid-sparing effect [34, 54–56]. Oral dapsone 100–300 mg per day or minocycline 100 mg twice daily appear to be efficacious (Table 1).…”

Section: Managementmentioning

confidence: 99%

Diagnosis and management of parastomal pyoderma gangrenosum

Shen

2013

Gastroenterology Report

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“…Igualmente, hasta un 4% puede presentarse en niños, en los que es más común en relación con otras enfermedades 1,4 . Tiene ligero predominio por el sexo femenino 1,3,5 , presenta una relación mujer: hombre de 3.5:1 6 .…”

Section: Discussionunclassified

“…Entre las enfermedades sistémicas con las que se relaciona, la enfermedad inflamatoria intestinal (EII) es la más común, puesto que se halló en un 30% de los casos 1,2,5,7 . De ahí que se haya propuesto la existencia de antígenos con reacción cruzada en el intestino y la piel 1,5 .…”

Section: Discussionunclassified

Pyoderma gangrenosum- Case report

2017

Journal of the American Academy of Dermatology

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El pioderma gangrenoso es una enfermedad inflamatoria crónica, poco común, con una incidencia de 3 a 10 casos por millón de habitantes, su etiología aún se desconoce pero se ha asociado con múltiples condiciones sistémicas dentro de las que sobresale la enfermedad inflamatoria intestinal. Hasta el momento se conocen cuatro variantes clínicas y la más común de todas es la forma ulcerativa. El diagnóstico es principalmente clínico y de descarte. En la histología se caracteriza por un infiltrado neutrofílico de la dermis. El tratamiento de elección son los glucocorticoides orales, aunque hay otras opciones terapéuticas descritas. Reportamos un caso representativo de un pioderma gangrenoso ulcerativo asociado con enfermedad inflamatoria intestinal. Palabras clave: pioderma gangrenoso; enfermedades inflamatorias del intestino; colitis ulcerosa.

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“…Furthermore, the inflammatory response in pustular neutrophilic folliculitis could possibly also resemble that of perifolliculitis capitis, acne, and hidradenitis suppurativa, which are inflammatory conditions marked by elevations in certain cytokines including TNF‐alpha and which have also been shown to respond to TNF‐alpha inhibitors . Finally, it is conceivable that neutrophilic folliculitis may be a forme fruste of pyoderma gangrenosum as pustular folliculitis has been described as part of the spectrum of pyoderma gangrenosum in patients with inflammatory bowel disease . Also, suppurative folliculitis has been described in a patient with acute myeloblastic leukemia as well as in a patient with Crohn's disease exposed to azathioprine .…”

Section: Discussionmentioning

confidence: 99%

A case of refractory chronic neutrophilic pustular folliculitis treated with adalimumab

Sand

Thomsen

2014

Dermatol Ther

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Neutrophilic folliculitis is an often overlooked chronic condition characterized by a monomorphic eruption of "sterile" papulopustules. Neutrophilic folliculitis is often refractory to conventional treatment with topical and systemic antibiotics or isotretinoin. We report a case of severe pustular neutrophilic folliculitis successfully treated with the tumor necrosis factor-alpha inhibitor adalimumab.

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Neutrophilic Folliculitis and the Spectrum of Pyoderma Gangrenosum in Inflammatory Bowel Disease

Cited by 11 publications

References 57 publications

Diagnosis and management of parastomal pyoderma gangrenosum

Diagnosis and management of parastomal pyoderma gangrenosum

Pyoderma gangrenosum- Case report

A case of refractory chronic neutrophilic pustular folliculitis treated with adalimumab

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