Neutrophilia and congestive heart failure after acute myocardial infarction

Kyne, Lorraine; Hausdorff, Jeffrey M.; Knight, Eric L.; Dukas, Larent; Azhar, Gohar; Wei, Jeanne Y.

doi:10.1016/s0002-8703(00)90314-4

Cited by 119 publications

(79 citation statements)

References 47 publications

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“…Active neutrophils also secrete several proteolytic enzymes such as myeloperoxidase, acid phosphatase, and elastase which help destroying tissue structure, and neutrophil-driven microvascular obstruction can worsen ischemia and lead infarct expansion, as well [13][14][15][16][17]. Several investigators reported that increased number of circulating neutrophils was independently related to risk of heart failure and mortality in long-term following MI [18,19]. In the other way, lymphocytopenia is a common finding secondary to increased corticosteroid levels induced by stress of coronary event [20].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction

et al. 2016

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Background: Acute inferior ST-segment elevation myocardial infarction (STEMI) is associated with increased in-hospital morbidity and mortality particularly among patients with coexisting right ventricular (RV) involvement. High neutrophil to lymphocyte ratio (NLR) is an independent predictor of major adverse cardiac events and mortality in patients with myocardial infarction. This study evaluated the relationship between the NLR and RV dysfunction (RVD) in patients with inferior STEMI who underwent primary percutaneous coronary intervention (PCI). Methods: A total of 213 subjects with inferior STEMI were divided into two groups according to the presence of RVD. The groups were compared according to NLR and receiver operating characteristic (ROC) analysis was performed to access the predictability of NLR on having RVD. Results: The NLR was significantly higher in the group with RVD compared to that without RVD (p < 0.001). In ROC analysis, NLR > 3.5 predicted RVD with sensitivity of 83% and specificity of 55%. In a multivariate regression analysis, NLR remained an independent predictor of RVD (OR 1.55, p < 0.001

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Section: Discussionmentioning

confidence: 99%

Neutrophil/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction

et al. 2016

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“…22 Furthermore, the role of granulocytes in the egress of stem cells into PB is also supported by the occurrence of granulocytosis, which is rapidly induced by CC during infection or organ damage and precedes egress of stem cells (for example, heart infarct). 89,90 All these phenomena are directly regulated by C5a anaphylatoxin, which binds to the G-protein-coupled, seven-transmembrane-spanning C5aR present on granulocytic cells and myeloid precursors. 22 At the same time our preliminary data suggest that another C5a/ desArg C5a-binding receptor C5L2 is not involved in the mobilization process.…”

Section: Involvement Of Granulocytes In Mobilizationmentioning

confidence: 99%

Innate immunity as orchestrator of stem cell mobilization

et al. 2010

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“…The primary clinical outcome was 30-day mortality. In addition, we analysed other clinically important outcomes, including the development of heart failure, defined as new episodes of congestive heart failure on the basis of clinical findings consistent with this diagnosis documented in the medical records, in association with echocardiographic evidence of contractile dysfunction (ejection fraction <40%) 35,36 . Statistical analysis.…”

Section: Discussionmentioning

confidence: 99%