Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in Chinese Han population from Chaoshan region in South China

Wu, Lingjie; Zou, Shien; Wang, Cantian; Tan, Xuerui; Yu, Min

doi:10.1186/s12872-019-1110-7

Cited by 69 publications

(70 citation statements)

References 30 publications

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“…This might be due to an insufficient sample size of patients with high creatinine level (n = 57 in our study), although we had a relatively large overall sample. In addition, previous study pointed out that the value of PLR varied with age and sex [34], we therefore performed a subgroup analysis to verify whether the predictive value of PLR was consistent among different populations. The subgroup analysis also confirmed that the relationship between PLR and mortality remained stable across all the age groups, as well as male or female subgroups.…”

Section: Discussionmentioning

confidence: 99%

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture

Wang¹,

Wang²,

Yang³

et al. 2020

International Orthopaedics (SICOT)

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Purpose The platelet-to-lymphocyte ratio (PLR) has been extensively studied in various diseases. However, the relationship between PLR and hip fracture remains unknown. The aim of this study was to evaluate whether PLR would be an independent prognostic factor in elderly hip fracture patients. Methods Between January 2014 and December 2018, a retrospective cohort study was conducted in a orthopaedic centre, China. A total of 460 hip fracture patients were included. PLR was calculated as the ratio of platelet to lymphocyte counts and divided into high PLR group (≥ 189) and low PLR group (< 189) by using the receiver operating characteristic (ROC) curve. The relationship between PLR and one year all-cause mortality rate was assessed by univariate and multivariate Cox proportional hazard models. Further subgroup analysis stratified by different clinical and biological characteristics was performed to make the results more accurate. Results After a median follow-up of 32.0 months (range, 12.0-75.4), 92 patients (mortality rate: 20.0%) died within one year. PLR was significantly higher in dead patients compared with alive patients (p < 0.05), and high PLR group also had a high mortality rate (32.21% vs. 14.15%, p < 0.001). After multivariate adjustment, high PLR remained an independent predictor for one year all-cause mortality (adjusted hazard ratio (HR) 1.56, 95% confidence interval (CI) 1.02-2.41, p = 0.041). Moreover, advanced age (HR 1.05, 95% CI 1.01-1.08), male (HR 1.62, 95% CI 1.06-2.45), CCI ≥ 2 (HR 2.83, 95% CI 1.64-4.89), conservative treatment (HR 5.94, 95% CI 3.71-9.73), low haemoglobin level (HR 1.02, 95% CI 1.01-1.04), and low albumin level (HR 1.07, 95% CI 1.02-1.13) were independent risk factors for survival. Furthermore, subgroup analysis results were consistent with the main findings in most stratified groups. Conclusion This study highlights that high PLR (≥ 189) is associated with increased one year all-cause mortality in elderly hip fracture patients. As PLR is a simple indicator that can be calculated from the blood routine test, it can be easily performed in usual clinical practice.

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Section: Discussionmentioning

confidence: 99%

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture

Wang¹,

Wang²,

Yang³

et al. 2020

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…41 Although PLR has been shown to be associated with prognosis of lung cancer in previous studies, studies on a predictive role of PLR in development of lung cancer are currently limited. [29][30][31][32] Previous studies reported a sex difference in PLR, with higher PLR in women than in men, 42,43 but studies address sex differences in the relationship between PLR and lung cancer risk are scarce. Although the mechanisms of sex-related differences in PLR are not fully understood, several factors, such as estrogen and low iron saturation in menstruating women, may affect platelet counts.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Kang

Chang

Ahn

et al. 2019

Intl Journal of Cancer

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Neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor prognosis in patients with lung cancer, but the predictive role of NLR on the risk of developing lung cancer is unknown. We investigated the association between NLR and lung cancer mortality in lung cancer‐free adults. A cohort study was performed with 527,124 Korean adults who were free of lung cancer and were followed for up to 16 years. Vital status and lung cancer‐related deaths were ascertained through national death records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer mortality were estimated using a Cox proportional hazards model. During 4,567,495.8 person‐years of follow‐up, 574 lung cancer deaths were identified. A higher NLR was positively associated with lung cancer mortality. The multivariable‐adjusted HR (95% CI) for lung cancer mortality comparing quintiles 2, 3, 4 and 5 of NLR to the lowest quintile were 1.26 (0.96–1.67), 1.23 (0.93–1.63), 1.33 (1.01–1.75) and 1.47 (1.13–1.92), respectively. The highest risk of lung cancer mortality was also observed in the highest NLR quintile among never‐smokers and low‐risk individuals after adjusting for lung function and other possible confounders. Platelet‐to‐lymphocyte ratio showed an inverse J‐shaped association with lung cancer mortality in men but the trends in women, low‐risk individuals or never‐smokers were neither linear nor U‐shaped. In this large cohort of young and middle‐aged individuals, NLR was independently associated with increased risk of lung cancer mortality in low‐risk individuals, indicating a role of systemic inflammation in lung cancer mortality in our study population.

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“…Platelet to lymphocyte ratio (PLR) is an indicator of prognosis in cardiovascular diseases, rheumatic disorders, infectious diseases, and organ injuring disorders such as systemic erythematous lupus (SLE) and malignancies [ 10 , 12 ] Platelets have dual properties involving both hemostasis and immunity [ 13 , 14 ]. This ratio is easily accessible and is calibrated by a complete blood count (CBC) test [ 15 ]. The platelet to lymphocyte ratio is also dependent upon age and gender, with women detected with elevated PLR at the age of 30–59 and decreased levels at the age of 50 as compared to males [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Hematological parameters predicting severity and mortality in COVID-19 patients of Pakistan: a retrospective comparative analysis

Asghar

Khan

Kazmi

et al. 2020

Journal of Community Hospital Internal Medicine Perspectives

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Background and Objectives: COVID-19 is a global pandemic. In our study, we aimed to utilize the hematological parameters in predicting the prognosis and mortality in COVID-19 patients. Materials and methods: A retrospective, observational study was conducted to include all the admitted patients (n = 191) having COVID-19 Polymerase chain reaction (PCR) positive, and evaluated those for prognosis and disease outcome by utilizing several biochemical and hematological markers. Results: Amongst the patients admitted in the ward versus in the intensive care unit (ICU), there were significant differences in mean hemoglobin (P = 0.003), total leukocyte count (P = 0.001), absolute neutrophil and lymphocyte counts (P < 0.001), absolute monocyte count (P = 0.019), Neutrophil-to-Lymphocyte ratio (NLR) and Lymphocyte-to-Monocyte ratio (LMR) (P < 0.001), Platelet-to-Lymphocyte ratio (PLR) and Lymphocyte-to C-reactive protein ratio (LCR) (P = 0.002), and C-reactive protein (CRP) levels (P < 0.001). Amongst the deceased patients, there was significant leukocytosis (P = 0.008), neutrophilia and lymphopenia (P < 0.001), increased NLR (P = 0.001), decreased LMR (P < 0.001), increased PLR (p = 0.017), decreased LCR (p = 0.003), and elevated CRP level (P < 0.001). A receiver operating characteristic curve obtained for the above parameters showed NLR (AUC: 0.841, PPV: 83.6%) and PLR (AUC: 0.703, PPV: 81.8%) for ICU patients, while NLR (AUC: 0.860, PPV: 91.1%) and PLR (AUC: 0.677, PPV: 87.5%) for the deceased patients had significant accuracy for predicting the disease severity of COVID-19 in comparison to survivors. Conclusion: The inflammatory markers and hematological indices are a good guide for predicting the severity and disease outcome of coronavirus disease. NLR and PLR are elevated in severe disease while LMR and LCR are inversely correlating with disease severity.

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in Chinese Han population from Chaoshan region in South China

Cited by 69 publications

References 30 publications

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture

Neutrophil‐to‐lymphocyte ratio and risk of lung cancer mortality in a low‐risk population: A cohort study

Hematological parameters predicting severity and mortality in COVID-19 patients of Pakistan: a retrospective comparative analysis

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