Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes

Nikolić, Igor; Kukulj, Suzana; Samaržija, Miroslav; Jeleč, Vjekoslav; Žarak, Marko; Orehovec, Biserka; Taradi, Ida; Romić, Dominik; Kolak, Toni; Patrlj, Leonardo

doi:10.3325/cmj.2016.57.287

Cited by 25 publications

(18 citation statements)

References 16 publications

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“…Indeed, high platelet count is associated with increased mortality in a variety of cancers, including malignant mesothelioma (11), gynecologic malignancies (12), and breast cancer (13). In addition, platelet-to-lymphocyte ratio and mean platelet volume also add value in early diagnosis of lung cancer (14) and prognosis prediction (15,16). These findings, taken together, indicate that disordered platelet production may be connected to lung carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Zhu

Wei

Zhang

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P ¼ 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P ¼ 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings.Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention.Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

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Section: Introductionmentioning

confidence: 99%

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Zhu

Wei

Zhang

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Mounting evidence has supported that systemic inflammation is related to shorter survival among patients with many cancers through promotion of cancer cell proliferation and survival, angiogenesis, and tumor metastasis [ 4 , 5 ]. Inflammation-based prognostic scores including platelet-to-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS) and mGPS have been reported to have prognostic efficacy for patients with cancers [ 6 , 7 ]. mGPS is a useful prognostic score for lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinical utility of the modified Glasgow prognostic score in lung cancer: A meta-analysis

Jin

Zhou

et al. 2017

PLoS ONE

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ObjectiveTo perform a meta-analysis of prospective and retrospective studies exploring the association of the modified Glasgow prognostic score (mGPS) with overall survival (OS) in patients with lung cancer.MethodsRelevant studies were identified by searching the Cochrane Library, Web of Science, Embase and PubMed until April 16, 2017. We combined hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the correlation between mGPS and OS in patients with lung cancer.ResultsEleven studies involving 5817 participants from several countries were included in the meta-analysis. In a pooled analysis of all studies, elevated mGPS predicted poorer OS (HR = 1.77; 95% CI: 1.35–2.31; P<0.05). Subgroup analyses stratified by mGPS showed that mGPS of 1 or 2 and mGPS≥1 were predictive of poorer OS and that the HR for mGPS of 2 (HR = 5.82; 95% CI: 1.85–18.22; P = 0.003) was significantly greater than that for mGPS of 1 (HR = 1.74; 95% CI: 1.24–2.45; P = 0.001) and mGPS≥1 (HR = 1.42; 95% CI: 1.14–1.76; P = 0.002). Among patients undergoing surgery, elevated mGPS had a non-significant correlation with reduced OS (HR = 2.48; 95% CI: 0.90–6.85; P = 0.079), whereas the correlation was significant for patients receiving chemotherapy or other palliative treatment (HR = 1.74; 95% CI: 1.31–2.30; P<0.05).ConclusionsOur findings indicate that mGPS may have prognostic value in lung cancer, as we detected a significant association between elevated mGPS and poorer OS. The association between mGPS and poorer OS was non-significant among patients undergoing surgery, which may be attributable to lower tumor load. However, further studies are warranted to draw firm conclusions.

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“…No significant difference was determined between the groups according to NLR and PLR. Nikolić et al [25] showed significantly higher NLR and PLR values in lung cancer patients (n=388) in comparison with a control group (n=47), but no difference was observed between subgroups of the lung cancer patients [25]. In the current study, NLR was significantly correlated with the SUV max ratios of spleen/aorta, spleen/liver, mass/aorta, mass/liver, and with the SUV mean ratios of spleen/aorta, bone marrow/aorta, spleen/ liver, and bone marrow/liver.…”

Section: Discussionmentioning

confidence: 99%

Association of PET Scan Parameters of Pulmonary Masses and Reticuloendothelial System with Hematologic Parameters

Kömek¹,

Altindag²,

Can³

2017

J Nucl Med Radiat Ther

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Objectives: The most active organs of the reticuloendothelial system (RES) are the liver, spleen and bone marrow, having immune mechanisms against malignancy including neutrophils and platelets. RES may be imaged by different modalities, like PET scan. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) have gained importance as proinflammatory markers in cancer, e.g. lung cancer. The aim of this study was to investigate the relationship between PET parameters of pulmonary mass or RES, and hematological parameters, and to evaluate the role of these factors in differentiating the pathological character of the mass. Methods:A retrospective analysis of the data of 131 patients, retrieved from the department archives, with pulmonary mass limited to mediastinum was made. Patients were grouped according to pathological results: benign mass (n=46), squamous cell carcinoma (n=38), and non-squamous cancer of lung (n=47). All patients underwent PET/CT scanning and images were analyzed retrospectively. Maximum and mean SUV were calculated from primary lesions and RES. NLR and PLR were calculated from CBC.Results: SUV max and SUV mean of RES organs were similar for both groups with benign and malignant pulmonary masses, and among the subgroups. SUV max ratios of pulmonary mass were significantly different between the groups (the highest value in the squamous cell carcinoma and the lowest in the benign groups). No significant difference was determined between the subgroups for NLR and PLR. NLR was significantly correlated with SUV max ratios of spleen and the mass, and SUV mean ratios of spleen and bone marrow. PLR was significantly correlated with SUV max ratios of spleen, bone marrow, the mass and SUV mean ratios of spleen, bone marrow. Conclusion:SUV of RES and primary mass were correlated with NLR and PLR, indicators of systemic inflammation. The associations between NLR and PLR, and SUV should be clearly defined by further investigations.

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes

Cited by 25 publications

References 16 publications

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Clinical utility of the modified Glasgow prognostic score in lung cancer: A meta-analysis

Association of PET Scan Parameters of Pulmonary Masses and Reticuloendothelial System with Hematologic Parameters

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