2000
DOI: 10.1016/s0735-1097(00)00916-5
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Abstract: Oxidative stress is increased in ischemic and nonischemic CHF, and neutrophils may be an important cause. Vitamin C reduces oxidative stress, increases FMD and, when given long term, decreases neutrophil O2- generation, but the lack of a correlation between changes in endothelial function and oxidative stress with vitamin C implies possible additional non-antioxidant benefits of vitamin C.

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Cited by 127 publications
(103 citation statements)
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“…18,19 The yet unsolved question is whether high OS merely reflects the HF progression, or is it actively participating in the disease progression? Several mechanisms may explain an active role of OS in the deterioration of the HF disease.…”
Section: Discussionmentioning
confidence: 99%
“…18,19 The yet unsolved question is whether high OS merely reflects the HF progression, or is it actively participating in the disease progression? Several mechanisms may explain an active role of OS in the deterioration of the HF disease.…”
Section: Discussionmentioning
confidence: 99%
“…It is unlikely that vitamin C acts through blood-borne neutrophils to enhance bacterial killing, since injection of 2000 mg ascorbate in human subjects does not alter superoxide production by neutrophils isolated from blood (16). However, infected patients often have bacteria in their interstitial fluid, too.…”
Section: Bacterial Replicationmentioning
confidence: 99%
“…we can conclude from our findings that oxidative stress has probably caused changes in blood flow and forearm vascular conductance in obese children, since the muscle vasodilator response was restored after supplementation with vitamin C 23,24 .…”
Section: Post-interventionmentioning
confidence: 51%
“…Studies with obese hypertensive patients or patients with heart failure 6,21,22 have shown that ascorbic acid levels are decreased in these groups when compared to control. There, we concluded that the lower concentration of ascorbic acid could have been caused by excessive oxidative stress 23 . In our study, it was not possible to complete this assessment, since the methodology employed was not sensitive enough to detect changes caused by chronic use of vitamin C. Yet, …”
Section: Baseline Forearm Vascular Conductance (Units) Eutrophic Obesmentioning
confidence: 89%
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