Neutrophil-lymphocyte ratio is increased in elderly patients with first episode depression, but not in recurrent depression

Arabska, Jaśmina; Łucka, Anna; Magierski, Radosław; Sobów, Tomasz; Wysokiński, Adam

doi:10.1016/j.psychres.2018.02.043

Cited by 27 publications

(12 citation statements)

References 31 publications

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“…The results are in agreement with previous research that identified higher NLR in patients with AD when compared to age-matched controls ( Kuyumcu et al, 2012 ; Rembach et al, 2014 ). The NLR ratio has also been associated with conditions related to AD risk and influencing progressions, such as CVD ( Angkananard et al, 2018 ; Kim et al, 2018 ; Haybar et al, 2019 ), obstructive sleep apnea ( Altintas et al, 2015 ; Sunbul et al, 2015 ; Oyama et al, 2016 ; Rha et al, 2020 ), depression ( Aydin Sunbul et al, 2016 ; Demircan et al, 2016 ; Arabska et al, 2018 ; Liang et al, 2019 ), and obesity ( Rodriguez-Rodriguez et al, 2020 ). Our findings are therefore consistent with previous research that identified an association of the NLR with AD and related risk factors.…”

Section: Discussionmentioning

confidence: 99%

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

Ramos‐Cejudo

Johnson

Beiser

et al. 2021

Front. Aging Neurosci.

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Objective: Active neutrophils are important contributors to Alzheimer’s disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and through aberrant neutrophil signaling that advances disease progression. The neutrophil to lymphocyte ratio (NLR) is a proxy of neutrophil-mediated inflammation, and higher NLR is found in persons diagnosed with clinical AD. The objective of this study was to investigate whether increased NLR in older adults is independently associated with the risk of subsequent dementia.Methods: We examined associations of baseline NLR with incident dementia risk in the community-based Framingham Heart Study (FHS) longitudinal cohorts. The association between NLR and risk of dementia was evaluated using the cumulative incidence function (CIF) and inverse probability-weighted Cox proportional cause-specific hazards regression models, with adjustment for age, sex, body mass index (BMI), systolic and diastolic blood pressure, diabetes, current smoking status, low-density lipoprotein (LDH), high-density lipoprotein (LDL), total cholesterol, triglycerides, and history of cardiovascular disease (CVD). Random forest survival models were used to evaluate the relative predictive value of the model covariates on dementia risk.Results: The final study sample included 1,648 participants with FHS (average age, 69 years; 56% women). During follow-up (median, 5.9 years), we observed 51 cases of incident dementia, of which 41 were AD cases. Results from weighted models suggested that the NLR was independently associated with incident dementia, and it was preceded in predictive value only by age, history of CVD, and blood pressure at baseline.Conclusion: Our study shows that individuals with higher NLR are at a greater risk of subsequent dementia during a 5.9-year follow-up period. Further evaluating the role of neutrophil-mediated inflammation in AD progression may be warranted.

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Section: Discussionmentioning

confidence: 99%

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

Ramos‐Cejudo

Johnson

Beiser

et al. 2021

Front. Aging Neurosci.

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“…NLR is calculated as ratio between absolute NEUT count and absolute LYM count. In a previous study, it was reported that NLR is increased in elderly patients after the first episode of depression (Arabska et al, 2018). Additionally, the NLR was significantly higher in unmedicated patients with depression than in healthy controls (2.10 ± 2.13 vs 2.01 ± 0.75, p = 0.004), and it was higher after the first episode of depression than after recurrent episodes (2.11 ± 1.76 vs 1.64 ± 1.04, p < 0.05).…”

Section: Immune Factors Reference Rangementioning

confidence: 94%

Correlation between immune response and self-reported depression during convalescence from COVID-19

Yuan

Liu³

et al. 2020

Brain, Behavior, and Immunity

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Self-reported depression has been observed in coronavirus disease-2019 (COVID-19) patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during discharge from the hospital. However, the cause of this self-reported depression during the convalescent period remains unclear. Here, we report the mental health status of 96 convalescent COVID-19 patients who were surveyed using an online questionnaire at the Shenzhen Samii Medical Center from March 2 to March 12, 2020 in Shenzhen, China. After obtaining their informed consent, we retrospectively analyzed the clinical characteristics of patients, including routine blood and biochemical data. The results suggested that patients with self-reported depression exhibited increased immune response, as indicated by increased white blood cell and neutrophil counts, as well as neutrophil-tolymphocyte ratio. However, the mechanism linking self-reported depression to these cellular changes needs further study. In conclusion, self-reported depression occurred at an early stage in convalescent COVID-19 patients, and changes in immune function were apparent during short-term follow-up of these patients after discharge. Appropriate psychological interventions are necessary, and changes in immune function should be emphasized during long-term follow up of these patients.

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“…Concerning unipolar depression, Mazza et al (2018) also confirmed that NLR increased in MDD compared with healthy controls [ 36 ]. NLR seems to be correlated with the disease severity in unipolar depressed patients although research data presents contradictory results on this subject [ 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers

Dionisie

Filip

Manea

et al. 2021

JCM

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(1) Background: Recent research suggests inflammation as a factor involved in the pathophysiology of mood disorders. Neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammatory (SII) index ratios have been studied as peripheral markers of inflammation in bipolar and major depressive disorders. The purpose of this study is to comparatively analyze these inflammatory ratios among manic episodes of bipolar disorder, bipolar depression and unipolar depression. (2) Methods: 182 patients were retrospectively included in the study and divided into three groups: 65 manic patients, 34 patients with bipolar depression, and 83 unipolar depressive patients. White blood cells, neutrophils, monocytes, lymphocytes, and platelets were retrieved from the patients’ database. NLR, MLR, PLR, and SII index were calculated using these parameters. (3) Results: Patients with manic episodes had elevated NLR (p < 0.001), MLR (p < 0.01), PLR (p < 0.05), and SII index (p < 0.001) compared to unipolar depression and increased NLR (p < 0.05) and SII index (p < 0.05) when compared to bipolar depression. NLR (p < 0.01) and SII index (p < 0.05) were higher in the bipolar depression than unipolar depression. NLR is an independent predictor of the bipolar type of depression in depressive patients. (4) Conclusions: The results confirm the role of inflammation in the pathophysiology of mood disorders and suggest the ability of NLR as a marker for the differentiation of bipolar from unipolar depression.

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Neutrophil-lymphocyte ratio is increased in elderly patients with first episode depression, but not in recurrent depression

Cited by 27 publications

References 31 publications

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

Correlation between immune response and self-reported depression during convalescence from COVID-19

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers

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