Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as markers of stable ischemic heart disease in diabetic patients: An observational study

Abstract

Ischemic heart disease (IHD) is a pressing public health concern with high prevalence, mortality, and morbidity. Although the value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as markers of the acute coronary syndrome are well recognized, there is a paucity of data deciphering their role in screening for stable ischemic heart disease (SIHD) in the presence of type 2 diabetes mellitus (T2DM). The present study investigates the value of NLR and PLR as markers of SIHD in T2DM. We evaluated the predictive value of NLR and PLR for SIHD by comparing T2DM patients having angiographically proven SIHD to T2DM patients without IHD at different cutoff levels by evaluating the area under the curve (AUC) obtained from receiver-operating-characteristic analysis. Raised NLR and PLR were significantly associated with SIHD ( P < .001 for each). On performing AUC-receiver-operating-characteristic analysis, NLR of > 2.39 and PLR of > 68.80 were associated with the highest prevalence of SIHD (NLR, AUC: 0.652 [0.605–0.699]; CI: 95%; P < .001, PLR, AUC: 0.623 [0.575–0.671] CI: 95%; P < .001). The sensitivities and specificities for these cutoff values were 50% and 73% for NLR and 73% and 46% for PLR, respectively. NLR and PLR were significantly higher in SIHD compared to those without; however, these markers had limited predictive potential in the setting of T2DM.

Preoperative Immunocyte-Derived Ratios Predict Postoperative Recovery of Gastrointestinal Motility after Colorectal Cancer Surgery

“…Presently, IDRs are extensively utilized across a diverse spectrum of medical disciplines as a dependable and conveniently accessible metric for gauging the immune reaction to a range of both infectious and noninfectious triggers. These ratios are subject to the influences of numerous factors, encompassing variables like diabetes, obesity, psychiatric disorders, solid organ malignancies, sepsis, pharmaceutical interventions, acute and chronic vascular disease, including coronary heart disease and stroke, and viral infections such as the SARS-CoV-2 virus [21,22]. Our analysis suggests that the preoperative values of three of the IDRs-namely, NLR, SII, and PLR, respectively-are elevated in POGD patients and seem to positively correlate with the duration of intestinal paresis, as assessed by the Tf, TL, and NGtR.…”

Utilization of NLR and PLR Data in Determining Prognosis of Diabetic Ulcer Patient

“…(Elsanan et al, 2023). Another study conducted by Joshi et al, (2023) also found that PLR could be a predictor of stable ischemic heart disease (SIHD) in diabetes mellitus patients with a sensitivity sensitivity of 73% and a specificity of 46% (Joshi et al, 2023).…”

Correlation between insulin resistance and the rate of neutrophils-lymphocytes, monocytes-lymphocytes, platelets-lymphocytes in type 2 diabetic patients

“…The findings announced a positive pertinence between NLR and fasting blood glucose (FBG), HOMA-IR. Within T2DM, elevated levels of NLR and PLR had been found to be positively associated with microalbuminuria [ 12 ], as well as being relevant to severity of carotid plaque [ 13 ] and stable ischemic heart disease [ 14 ]. Among individuals with diabetic retinopathy (DR), there was a notable elevation in the levels of NLR, MLR and PLR in comparison to those without DR [ 15 ].…”