Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study

Binici, Nagihan Cevher; Güney, Sevay Alşen

doi:10.1016/j.psychres.2018.08.065

Cited by 14 publications

(13 citation statements)

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“…These findings suggest the existence, of an association between manic state and inflammation in adolescents, similar to that found in adult patients (Munkholm et al, 2015;Cevher Binici et al, 2018;Mazza et al, 2018;Mazza et al, 2019;Brinn and Stone, 2020;Fusar-Poli et al, 2021;Marazziti et al, 2021;Özdin and Usta, 2021). The current study supports the notion that inflammation is involved in the emergence of bipolar manic states, already at adolescence (Sayana et al, 2017).…”

Section: Discussionsupporting

confidence: 90%

“…A study on adolescent inpatients with nonaffective psychosis also reported elevated NLR (Bustan et al , 2018). Literature on the association between severe mood disorders and inflammation in children and adolescents with neuropsychiatric disorders is limited (Goldstein et al , 2011; Mitchell and Goldstein, 2014; Binici et al , 2018; Özyurt and Binici, 2018). Cevher Binici et al (2018) found no differences in NLR between adolescents with bipolar disorder and controls.…”

Section: Introductionmentioning

confidence: 99%

“…Literature on the association between severe mood disorders and inflammation in children and adolescents with neuropsychiatric disorders is limited (Goldstein et al , 2011; Mitchell and Goldstein, 2014; Binici et al , 2018; Özyurt and Binici, 2018). Cevher Binici et al (2018) found no differences in NLR between adolescents with bipolar disorder and controls. They, however, suggest that further studies are needed to investigate changes in this parameter during the various episodes of bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

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Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward

Drapisz

Avrahami

Dor

et al. 2022

International Clinical Psychopharmacology

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Inflammatory processes are associated with mood disorders, but data on pediatric patients are scarce. The aim of this study was to investigate a possible association between elevated neutrophil/lymphocyte ratio (NLR) -a marker of inflammation and mood polarity (manic/ depressed) in adolescents, admitted between 2010 and 2015 due to a mood disorder episode and to an adolescent inpatient ward. Electronic medical records of 305 patients (aged 10-19 years, 60.6% males) admitted during the study period due to a mood disorder episode were reviewed. Of these, 63 were diagnosed with manic episodes and 242 with depressive episodes. Multivariate analyses were used to compare NLR between and within the two groups, covarying for age, sex, and antipsychotic use. NLR was significantly higher in the manic episode group compared with the depression one. Moreover, in inpatients with multiple hospitalizations, the NLR was higher during their manic episodes than that during their nonmanic states. These results suggest that, as has been reported in adults with bipolar disorder, inflammatory mechanisms may be involved in adolescents' mood disorders as well, particularly in the manic episodes. Thus, clinicians may consider adding anti-inflammatories as part of the treatment of these patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward

Drapisz

Avrahami

Dor

et al. 2022

International Clinical Psychopharmacology

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“…Of the remaining publications, 1 was excluded from the review due to the unavailability of the full text. After reviewing the full texts of 24 articles, we included 11 publications in the review [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. The main reason for exclusion from analysis was that the studies were ineligible due to the age of the participants ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review

Popov,

Kosterin

et al. 2024

Consortium Psychiatricum

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BACKGOUND: Inflammatory hematological ratios (IHRs), such as neutrophil to lymphocyte, monocyte to lymphocyte, and platelet to lymphocyte ratios, are associated with mental disorders, symptoms severity, and the disease phase. Evidence from the studies in adult patients has been summarized in systematic reviews and meta-analyses. The results of the studies in adolescents remain poorly systematized. AIM: To summarize the findings from the studies that investigated the relationship of IHRs with mental disorders in adolescent patients. METHODS: This scoping review included studies of IHRs in patients aged 10–19 years with mental disorders (other than anorexia nervosa), published in English by December 31, 2023. The search for relevant papers was performed in MEDLINE. The studies were categorized into two groups: studies with external controls (healthy adolescents) and studies with internal controls (patients in different phases of mental disorder, with or without self-harm/suicidal behaviors). RESULTS: A total of 11 studies were included in the review (all cross-sectional ones). The results of these studies demonstrate that 1) adolescents with mental disorders (major depressive disorder, psychotic disorders, obsessive-compulsive disorder, attention deficit hyperactivity disorder, substance use disorders) have higher IHR values than individuals of the same age without corresponding disorders (5 studies); 2) IHR values are positively correlated with the severity of psychopathological symptoms (1 study); 3) higher IHR values are associated with the phase of the mental disorder — manic episode in bipolar disorder (1 study) and exacerbation of psychosis in psychotic disorders (1 study); and 4) higher IHR values are associated with self-harm/suicidal behaviors — suicide attempts (1 study) and non-suicidal self-injury (1 study). CONCLUSION: IHRs are associated with mental disorders in adolescents, and higher IHR values are associated with a more severe/acute clinical presentation (severity of symptoms, mania, acute psychosis, self-harm/suicidal behaviors). Further studies of higher methodological quality are needed to evaluate the diagnostic and prognostic value of IHRs as biomarkers of mental disorders in adolescence.

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“…The exciting finding is that most of the variants found and three variants related to BD were related to hemogram parameters, such as lymphocyte percentage, nucleated red blood cell, neutrophil count, lymphocyte counts, eosinophil counts, haemoglobin concentration, white blood cell count, haematocrit, plateletcrit, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular volume. The relationship among these indicators and BD has been concluded in various epidemiological studies (Altshuler et al, 2008;Wysokiński & Margulska, 2017;Ivković et al, 2016;Cevher Binici et al, 2018;Çakır et al, 2015;Wysokiński et al, 2015;Wysokiński & Szczepocka, 2018;Mert & Terzi, 2016;Mutz et al, 2021). During manic episodes, inflammatory cells (absolute neutrophil count, platelet count, plateletcrit and mean platelet volume) and ratios (neutrophil-lymphocyte ratio, platelet-lymphocyte ratio) appear to be altered, according to hemogram readings of individuals with BD compared to those of a healthy control group (Mert & Terzi, 2016).…”

Section: Discussionmentioning

confidence: 97%

Using the Bayesian variational spike and slab model in a genome‐wide association study for finding associated loci with bipolar disorder

Kazemi Naeini,

Akbarzadeh,

Kazemi

et al. 2023

Annals of Human Genetics

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ObjectiveThe genome‐wide association studies (GWAS) analysis, the most successful technique for discovering disease‐related genetic variation, has some statistical concerns, including multiple testing, the correlation among variants (single‐nucleotide polymorphisms) based on linkage disequilibrium and omitting the important variants when fitting the model with just one variant. To eliminate these problems in a small sample‐size study, we used a sparse Bayesian learning model for finding bipolar disorder (BD) genetic variants.MethodsThis study used the Wellcome Trust Case Control Consortium data set, including 1998 BD cases and 1500 control samples, and after quality control, 380,628 variants were analysed. In this GWAS, a Bayesian logistic model with hierarchical shrinkage spike and slab priors was used, with all variants considered simultaneously in one model. In order to decrease the computational burden, an alternative inferential method, Bayesian variational inference, has been used.ResultsThirteen variants were selected as associated with BD. The three of them (rs7572953, rs1378850 and rs4148944) were reported in previous GWAS. Eight of which were related to hemogram parameters, such as lymphocyte percentage, plateletcrit and haemoglobin concentration. Among selected related genes, GABPA, ELF3 and JAM2 were enriched in the platelet‐derived growth factor pathway. These three genes, along with APP, ARL8A, CDH23 and GPR37L1, could be differential diagnostic variants for BD.ConclusionsBy reducing the statistical restrictions of GWAS analysis, the application of the Bayesian variational spike and slab models can offer insight into the genetic link with BD even with a small sample size. To uncover related variations with other traits, this model needs to be further examined.

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Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study

Cited by 14 publications

References 40 publications

Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward

Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward

Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review

Using the Bayesian variational spike and slab model in a genome‐wide association study for finding associated loci with bipolar disorder

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