2014
DOI: 10.1038/mi.2013.126
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Abstract: Neutrophil infiltration is a key event in chronic intestinal inflammation and associated colorectal cancer, but how these cells support cancer development is poorly understood. In this study, using a mouse model of colitis-associated cancer (CAC), we have demonstrated that infiltrated neutrophils produce large amounts of interleukin-1 (IL)-1β that is critical for the development of CAC. Depletion of neutrophil or blockade of IL-1β activity significantly reduced mucosal damage and tumor formation. This protumor… Show more

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Cited by 114 publications
(91 citation statements)
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“…This phenomenon can be observed both in vitro and in vivo in CRC models, as microbial products from commensal colon microbiota activate TLRs and downstream pathways. Upregulation of IL-23 (as well as IL-6 and IL-1β), in particular, leads to activation of an IL-17A response, which is an important tumor promoter both in CAC and CRC (10,26,(45)(46)(47)(48). Here, GTN treatment also prevented the upregulation of IL-23 and decreased IL-17A expression in CRC tumors, suggesting that GTN could modulate this important pathway and thus have promising activity in CRC models.…”
Section: Discussionmentioning
confidence: 57%
“…This phenomenon can be observed both in vitro and in vivo in CRC models, as microbial products from commensal colon microbiota activate TLRs and downstream pathways. Upregulation of IL-23 (as well as IL-6 and IL-1β), in particular, leads to activation of an IL-17A response, which is an important tumor promoter both in CAC and CRC (10,26,(45)(46)(47)(48). Here, GTN treatment also prevented the upregulation of IL-23 and decreased IL-17A expression in CRC tumors, suggesting that GTN could modulate this important pathway and thus have promising activity in CRC models.…”
Section: Discussionmentioning
confidence: 57%
“…Increasing levels of IL-1 system in IBD may be a result of colonic macrophages stimulation that activates IL-1 converting enzyme/caspase 1 (ICE) and thus release the mature IL-1b into the colonic mucosa 25 . Recently, IL-1β activity blockage was shown to reduce tumorigenesis in mice by impairing macrophage-dependent IL-6 secretion 26 . These findings imply that IL-1 has prominent role in the initiation of colonic inflammation 3 .…”
Section: Intestinal Inflammation and Tumor Microenvironment: Differenmentioning
confidence: 99%
“…IL-1b and IL-18 have key roles in inducing colorectal tumor formation [39][40][41]. One carcinogenic mechanism of this AOM/DSS model may be that IL-1b induced by neutrophils leads to macrophage production of IL-6, as a tumor promoter [42]. In addition, AOM/DSS Il18 -/-and Il18r1 -/-mice are more susceptible to colitis and polyp formation than wild-type mice are [41].…”
Section: Gut Microbiota and Experimental Models Of Ibdmentioning
confidence: 99%