Neutrophil Extracellular Traps - The Invisible Inflammatory Mediator in Fibrosis

Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders

“…Other myeloid cells prominently involved in inflammatory lung diseases [56,57] and fibrosis development [58,59] are neutrophils, which as a unique feature contain neutrophil extracellular traps (NET), composed of DNA fibers and cytoplasmic proteins. NET provide a solid defensive mechanism against pathogens, but they can also cause tissue damage via induction of hyper-inflammatory reactions.…”