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Cited by 65 publications
(56 citation statements)
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References 47 publications
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“…LDNs from healthy individuals produced fewer NETs than NDN, in direct contrast to LDNs isolated from chronic inflammatory conditions such as psoriasis and idiopathic inflammatory myopathy, where LDNs produce increased numbers of NETs. [14,15] It is difficult to reconcile many of the features of LDNs as healthy LDNs have normal expression of CD10 and CD16 characteristic of mature neutrophils and no reduction in ROS production in spite of having an immature nuclear morphology.…”
Section: Discussionmentioning
confidence: 99%
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“…LDNs from healthy individuals produced fewer NETs than NDN, in direct contrast to LDNs isolated from chronic inflammatory conditions such as psoriasis and idiopathic inflammatory myopathy, where LDNs produce increased numbers of NETs. [14,15] It is difficult to reconcile many of the features of LDNs as healthy LDNs have normal expression of CD10 and CD16 characteristic of mature neutrophils and no reduction in ROS production in spite of having an immature nuclear morphology.…”
Section: Discussionmentioning
confidence: 99%
“…In both Systemic Lupus Erythematosus (SLE) and Idiopathic inflammatory myopathy, neutrophil extracellular trap (NET) formation is increased in LDNs when compared to disease group NDNs and healthy control neutrophils. [15,19] In these and other studies 'control neutrophils' comprise neutrophils found in the PMN layer, isolated by Ficoll/Percoll gradient NET formation by healthy donor LDNs is therefore poorly described (Reviewed in Table 2). Healthy…”
Section: Ldns Show Decreased Net Formation But No Difference In Apoptmentioning
confidence: 99%
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