Neutron Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck

Sinonasal Adenoid Cystic Carcinoma

“…In this analysis, we found a similar survival percentage in the combination (surgery and radiotherapy) treatment group compared with surgery alone, 68.4% vs 63.2%. Two case series reported that the combination therapy cohort had greater survival than the radiotherapy‐only cohort, although this was not found to be statistically significant possibly due to small sample size 56,74 . We report that 68.4% of patients in the combination treatment group survived compared with just 42.1% undergoing radiotherapy alone.…”

Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity

“…3 8 We also demonstrated 5-year and 10-year LRFS values of 69.1% and 53.8%, respectively, possibly due to the selection of unresectable and locally advanced tumors. Bucholz et al 9 and Douglas et al 10 similarly reported 5-year LRFS of 76% and 63%, respectively. Tumor subsite in ACC of the head and neck has shown to have variable survival and LRFS.…”

Proton Therapy for Head and Neck Adenoid Cystic Carcinoma: A Multi-institutional Review

“…ACC is a rare salivary gland malignancy characterized by indolent growth and a high propensity for PNI. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 17 , 25 The current standard treatment paradigm for resectable disease consists of surgical resection to negative margins followed by postoperative RT, while definitive-intent high-dose RT is recommended for patients with inoperable disease. 14 , 32 , 33 , 34 Tumor extension along major cranial nerves often complicates management, as skull base invasion may render patients unresectable and necessitate delivery of high dose RT in close proximity to critical organs at risk which can limit desired target coverage with prescription dose.…”

“…Data from FNT have confirmed superior efficacy to X-ray-based RT for treatment of salivary gland cancers at the cost of worsened toxicity. 17 , 19 , 25 , 39 , 40 Therefore, alternative forms of particle therapy such as PBT and CIRT warrant further investigation. In addition to having a slightly higher RBE than x-ray-based RT, the physical properties of PBT allow for improved conformality of treatment plans and may allow for improved target coverage while simultaneously sparing adjacent organs at risk.…”