Neutral endopeptidase depletion decreases colon cancer cell proliferation and TGF-β1 synthesis in indirect co-cultures with normal colon fibroblasts

Mizerska-Kowalska, Magdalena; Sawa-Wejksza, Katarzyna; Sławińska-Brych, Adrianna; Kandefer‐Szerszeń, Martyna; Zdzisińska, Barbara

doi:10.1007/s12094-020-02537-x

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Further studies by Mizerska-Kowalska et al point to the involvement of CD10 in CRC cell growth, proliferation, migration, and invasiveness, which it mediates by regulating cancer cell motility via the Akt/FAK signaling pathways ( Mizerska-Kowalska et al, 2016 ). They also discovered that CD10 expression is vital for the synthesis of TGF-β1, and its inhibition corresponds with decreased levels of TGF-β1-a tumor suppressor known to curb cell proliferation and induce apoptosis through the upregulation of cell cycle inhibitors (like p21) and the activation of MAP kinases and PI3K/Akt pathways ( Mizerska-Kowalska et al, 2021 ).…”

Section: Role Of Cd10 In Different Types Of Diseasesmentioning

confidence: 99%

A comprehensive review of the literature on CD10: its function, clinical application, and prospects

Wang,

Xiao,

et al. 2024

Front. Pharmacol.

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CD10, a zinc-dependent metalloprotease found on the cell surface, plays a pivotal role in an array of physiological and pathological processes including cardiovascular regulation, immune function, fetal development, pain response, oncogenesis, and aging. Recognized as a biomarker for hematopoietic and tissue stem cells, CD10 has garnered attention for its prognostic potential in the progression of leukemia and various solid tumors. Recent studies underscore its regulatory significance and therapeutic promise in combating Alzheimer’s disease (AD), and it is noted for its protective role in preventing heart failure (HF), obesity, and type-2 diabetes. Furthermore, CD10/substance P interaction has also been shown to contribute to the pain signaling regulation and immunomodulation in diseases such as complex regional pain syndrome (CRPS) and osteoarthritis (OA). The emergence of COVID-19 has sparked interest in CD10’s involvement in the disease’s pathogenesis. Given its association with multiple disease states, CD10 is a prime therapeutic target; inhibitors targeting CD10 are now being advanced as therapeutic agents. This review compiles recent and earlier literature on CD10, elucidating its physicochemical attributes, tissue-specific expression, and molecular functions. Furthermore, it details the association of CD10 with various diseases and the clinical advancements of its inhibitors, providing a comprehensive overview of its growing significance in medical research.

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Section: Role Of Cd10 In Different Types Of Diseasesmentioning

confidence: 99%

A comprehensive review of the literature on CD10: its function, clinical application, and prospects

Wang,

Xiao,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Selenium Treatment Alleviates the Inhibition Caused by Nep-L Gene Knockdown in Silkworm (Bombyx mori)

Hong,

Hu,

et al. 2024

Biol Trace Elem Res

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TGF-β Signaling in Metastatic Colorectal Cancer (mCRC): From Underlying Mechanism to Potential Applications in Clinical Development

Tian

2022

IJMS

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Colorectal cancer (CRC) is a serious public health issue, and it has the leading incidence and mortality among malignant tumors worldwide. CRC patients with metastasis in the liver, lung or other distant sites always have poor prognosis. Thus, there is an urgent need to discover the underlying mechanisms of metastatic colorectal cancer (mCRC) and to develop optimal therapy for mCRC. Transforming growth factor-β (TGF-β) signaling plays a significant role in various physiologic and pathologic processes, and aberrant TGF-β signal transduction contributes to mCRC progression. In this review, we summarize the alterations of the TGF-β signaling pathway in mCRC patients, the functional mechanisms of TGF-β signaling, its promotion of epithelial–mesenchymal transition, its facilitation of angiogenesis, its suppression of anti-tumor activity of immune cells in the microenvironment and its contribution to stemness of CRC cells. We also discuss the possible applications of TGF-β signaling in mCRC diagnosis, prognosis and targeted therapies in clinical trials. Hopefully, these research advances in TGF-β signaling in mCRC will improve the development of new strategies that can be combined with molecular targeted therapy, immunotherapy and traditional therapies to achieve better efficacy and benefit mCRC patients in the near future.

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Neutral endopeptidase depletion decreases colon cancer cell proliferation and TGF-β1 synthesis in indirect co-cultures with normal colon fibroblasts

Cited by 4 publications

References 28 publications

A comprehensive review of the literature on CD10: its function, clinical application, and prospects

A comprehensive review of the literature on CD10: its function, clinical application, and prospects

Selenium Treatment Alleviates the Inhibition Caused by Nep-L Gene Knockdown in Silkworm (Bombyx mori)

TGF-β Signaling in Metastatic Colorectal Cancer (mCRC): From Underlying Mechanism to Potential Applications in Clinical Development

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