Neutral and charged phosphine/scorpionate copper(I) complexes: Effects of ligand assembly on their antiproliferative activity

Porchia, Marina; Dolmella, Alessandro; Gandin, Valentina; Marzano, Cristina; Pellei, Maura; Peruzzo, Valentina; Refosco, Fiorenzo; Santini, Carlo; Tisato, Francesco

doi:10.1016/j.ejmech.2012.11.022

Cited by 64 publications

(34 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mirabelli et al (1987) also showed that the ligands investigated in their study, had lower dosepotency in vivo than their corresponding chlorogold(I) complexes. Even though the ligand on its own is not toxic, beyond the nature of the metal, the choice of the appropriate ligand is extremely important since they affect the thermodynamic and kinetic stability of the compound as well as its solubility and lipophilicity (Porchia et al 2013).…”

Section: Resultsmentioning

confidence: 99%

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

et al. 2015

View full text Add to dashboard Cite

There is much interest currently in the design of metal compounds as drugs and various metal compounds are already in clinical use. These include gold(I) compounds such as auranofin and the anti-cancer platinum(II) complex, cisplatin. Bis-chelated gold(I) phosphine complexes have also shown great potential as anticancer agents, however, their efficacy has been limited by their high toxicity. In this study, silver(I) thiocyanate compounds linked to four specific ligands, were synthesized and characterized. These silver-phosphine adducts included [AgSCN{P(4-MeC6H4)3}2]2 (1); [AgSCN{P(4-ClC6H4)3}2]2 (2); [AgSCN{P(4-MeOC6H4)3}2]2 (3); [AgSCN(PPh3)2]2 (4). The compounds were found to be toxic to MCF-7 breast cancer cells while the ligands on their own were not toxic. Our findings further indicate that the silver(I) phosphine compounds induce apoptotic cell death in these breast cancer cells. In addition, the compounds were not toxic to nonmalignant fibroblast cells at the IC50 concentrations. This is an indication that the compounds show selectivity towards the cancer cells.

show abstract

Section: Resultsmentioning

confidence: 99%

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Some complexes, such as [Cu(N,N 0 -disubstituted thioureas)Cl] and [Cu(1,3,5-triaza-7-phosphaadamantane) 4 ] + , exhibit moderate cytotoxicity against various human cell lines (Porchia et al, 2009). In analogy with gold, Cu(I)-phosphine complexes have been synthesized and evaluated as antitumor compounds (Marzano et al, 2006;Plotek et al, 2013;Porchia et al, 2013;Santini et al, 2013). Some mixed Cu(I) complexes of triazolylborate and alkyl-or aryl-phosphines have been found to be effective against A549 adenocarcinoma cisplatin resistant cells (Marzano et al, 2006).…”

Section: Coppermentioning

confidence: 98%

Coordination compounds in cancer: Past, present and perspectives

Trudu¹,

Amato

Vaňhara³

et al. 2015

J Appl Biomed

133

View full text Add to dashboard Cite

“…Thus, the molecules showed infinite three-dimensional molecular networks parallel to the [1][2][3][4][5][6][7][8][9][10], [021] and [1][2][3][4][5][6][7][8][9][10][11] planes. …”

Section: [Cu(pydc)(mim) 3 ]·2h 2 O (2)mentioning

confidence: 99%

“…In biological systems, copper exists as a variety of complexes as coordinated forms of copper are more stable than the corresponding ionic species [8]. Several families of copper complexes comprising different ligands demonstrated notable anticancer activity [9][10][11][12][13][14][15]. Our choice of imidazole and pyridine derivatives is based on differences in their DNA binding ability.…”

Section: Introductionmentioning

confidence: 99%

Syntheses of crystal structures andin vitrocytotoxic activities of new copper(II) complexes of pyridine-2,6-dicarboxylate

Orhan

Çolak

Emen

et al. 2015

Journal of Coordination Chemistry

View full text Add to dashboard Cite

Cu(pydc)(im)] n (1), [Cu(pydc)(mim) 3 ]·2H 2 O (2), [Cu(pydc)(ampy)(H 2 O)]·H 2 O (3) and[Cu(pydc)(phen)][Cu(Hpydc) 2 ] (4) (H 2 pydc = 2,6-pyridinedicarboxylic acid or dipicolinic acid, im = imidazole, mim = 2-methylimidazole, ampy = 2-amino-4-methylpyridine and phen = 1,10-phenanthroline) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra) and single crystal X-ray diffraction. Complexes 1, 2 and 3 were studied by thermogravimetric analysis from ambient temperature to 1100 K under nitrogen and thermal stabilities were investigated. The effects of complexes on proliferation of fibrosarcoma cells were investigated using the Quick Cell Proliferation Assay. The cell viability changes depend on the concentrations and type of complexes. According to cell proliferation/viability data, 4 was determined to be the most cytotoxic.

show abstract

Neutral and charged phosphine/scorpionate copper(I) complexes: Effects of ligand assembly on their antiproliferative activity

Cited by 64 publications

References 39 publications

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

Coordination compounds in cancer: Past, present and perspectives

Syntheses of crystal structures andin vitrocytotoxic activities of new copper(II) complexes of pyridine-2,6-dicarboxylate

Contact Info

Product

Resources

About