Neurotropic Melanoma. A variant of desmoplastic melanoma

Kossard, S.

doi:10.1001/archderm.123.7.907

Cited by 28 publications

(37 citation statements)

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“…AFX stains positively for CD10, however, this marker is not specific for AFX, 19 and CD10 staining has been demonstrated in poorly differentiated squamous cell carcinoma and desmoplastic melanoma. [19][20][21][22] Desmoplastic melanoma shows positive staining for S100, but this may be focal and some cases may be S100 negative [23][24][25] ; furthermore, as additional melanoma markers typically are negative, interpretation of focally positive cells may be problematic. Although DFSP stains strongly for CD34, DFSP with sarcomatous transformation characteristically shows loss of CD34 expression.…”

Section: Discussionmentioning

confidence: 99%

SOX10 Expression Distinguishes Desmoplastic Melanoma From Its Histologic Mimics

Palla

Binder

et al. 2013

The American Journal of Dermatopathology

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Desmoplastic melanoma (DM) presents diagnostic challenges due to histologic mimics and limited immunohistochemical staining. Although S100 usually stains DM, other melanoma markers (HMB-45 and Melan-A) are often negative. Dermal/subcutaneous mimics of DM [spindle cell/poorly differentiated squamous cell carcinoma, atypical fibroxanthoma (AFX), and sarcoma] show negative or unreliable immunohistochemical staining. Recently, SOX10 expression has been shown to be a sensitive and specific marker of DM. However, there are no published studies comparing the sensitivity and specificity of SOX10 for DM compared with its most common histologic mimics of the dermis/subcutis. We examined 76 cases, including DM (n = 15), spindle cell/poorly differentiated carcinoma (n = 18), AFX (n = 13), sarcoma with spindled morphology (n = 20), and malignant peripheral nerve sheath tumor (MPNST) (n = 10). Most (75%, 15/20) of sarcomas were centered in the dermis/subcutis and included sarcoma not otherwise specified, DFSP with sarcomatous transformation and myxofibrosarcoma. SOX10 was diffusely positive in 100% (15/15) of DMs and showed focal staining in 30% (3/10) of MPNSTs. All other tumors were negative for SOX10 [0% (0/18) of carcinomas, 0% (0/13) of AFXs, 0% (0/20) of sarcomas]. In conclusion, SOX10 is a highly useful marker to confirm the diagnosis of DM. In our study, SOX10 showed 100% sensitivity for DM and SOX10 was negative in all histologic mimics of the dermis/subcutis, including spindle cell carcinoma, AFX and sarcomas. Similar to S-100 protein, some MPNSTs show scattered positivity but did not show diffuse positivity seen in DM.

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Section: Discussionmentioning

confidence: 99%

SOX10 Expression Distinguishes Desmoplastic Melanoma From Its Histologic Mimics

Palla

Binder

et al. 2013

The American Journal of Dermatopathology

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“…3,4,[11][12][13][14] Many authors have advocated generous surgical margins of up to 3 cm as a means to reduce the rate of local recurrences of DMM. [2][3][4]6,9 However, most lesions present in the head and neck, 5,9,10,15,16 where wide surgical excision can be associated with poor functional and cosmetic outcome. It should also be noted that even with negative surgical margins the rate of recurrence was still 40%.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma

et al. 2003

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“…Neurotropism is thought to significantly worsen the prognosis of melanoma by causing deeper infiltration into the soft tissues at the primary site and extension along peripheral nerves increasing the likelihood of margin involve-As these tumors are frequently located in the head and neck area, such neurotropism can give rise to cranial neuropathies due to direct extension of The purpose of this study is to evaluate the effects of both desmoplasia and neurotropism on the clinical presentation, clinical behavior, and survival outcome of prospectively diagnosed patients with primary cutaneous Stage I melanomas which are completely excised at the initial presentation of disease, prospectively registered into a database, and followed for more than 8 years. ment~5, 9,10,11,[20][21][22] tumor. 10.1 1 3…”

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confidence: 99%

Desmoplasia and neurotropism. Prognostic variables in patients with stage I melanoma

Baer

Schultz

Synnestvedt

et al. 1995

Cancer

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Background. Desmoplastic melanomas with and without neurotropism are thought to be more clinically aggressive than other melanomas of comparable thickness. This study evaluates the prognostic significance of desmoplasia and neurotropism in Patients with Stage I cutaneous melanoma completely excised at the initial presentation of disease and prospectively studied for a minimum of 8 years. Methods. Desmoplasia and neurotropism were evaluated as single prognostic predictors in survival outcome of cutaneous Stage I melanomas and as variables in the University of Pennsylvania Pigmented Lesion Study Group 8‐year survival model for Stage I melanoma. In addition, the clinical presentation and follow‐up of melanomas with desmoplasia and/or neurotropism was compared with that of other types of cutaneous Stage I melanoma in patients also followed for a minimum of 8 years. Results. Neurotropism was associated with a statistically significant decrease in survival in patients with melanomas with desmoplasia. A decrease in survival also was observed in other types of melanoma with neurotropism, but the difference was not statistically significant. Melanomas with neurotropism had a statistically significant increase in local recurrence. Desmoplasia was not associated with a statistically significant decrease in survival. Conclusion. Desmoplasia is not associated with a statistically significant decrease in the prognosis of patients with primary cutaneous Stage I melanoma. The more clinically aggressive behavior of desmoplastic melanomas observed in previous studies may be secondary to initial misdiagnosis and/or inadequate margin assessment of these lesions. Neurotropism, however, is associated with a statistically significant decrease in survival in patients with desmoplastic melanomas and is most likely associated with decreased reduces patient survival in other melanoma types. Neurotropism is also related to an increase in the frequency of local recurrence of melanoma. Cancer 1995; 76:2242–7.

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Neurotropic Melanoma. A variant of desmoplastic melanoma

Cited by 28 publications

References 0 publications

SOX10 Expression Distinguishes Desmoplastic Melanoma From Its Histologic Mimics

SOX10 Expression Distinguishes Desmoplastic Melanoma From Its Histologic Mimics

Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma

Desmoplasia and neurotropism. Prognostic variables in patients with stage I melanoma

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