Dora Krizsan-Agbas, Tetyana Pedchenko, Peter G. Smith
AbstractMechanisms underlying axon degeneration in peripheral neuropathies and during normal remodeling are poorly understood. Because estrogen induces widespread sympathetic axon degeneration within female reproductive tract smooth muscle, we surveyed estrogen-regulated genes in rat myometrium. Microarray analysis revealed that the neural cell adhesion protein neurotrimin (Ntm) was markedly upregulated at 6h and down-regulated by 24h after injection of 17β-estradiol and real time RT-PCR confirmed this patter…
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