Neurotransmitter changes in early- and late-onset alzheimer-type dementia

Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting Various Pathological Events and Alteration in Neurotransmitter Levels in Rat’s Brain

“…Aβ in both clinical and preclinical AD, has reports to causes catecholaminergic deficit by escalating AChE enzymatic activity [44,45]. In agreement with the previous findings, the present study also showed significant increase in AChE activity in Aβ infused brains [6][7][8][9][10]. However, the treatment of lupeol was able to significantly decrease AChE activity as reported earlier [17].…”

Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting Various Pathological Events and Alteration in Neurotransmitter Levels in Rat’s Brain

“…Aβ in both clinical and preclinical AD, has reports to causes catecholaminergic deficit by escalating AChE enzymatic activity [44,45]. In agreement with the previous findings, the present study also showed significant increase in AChE activity in Aβ infused brains [6][7][8][9][10]. However, the treatment of lupeol was able to significantly decrease AChE activity as reported earlier [17].…”

Embelin Improves the Spatial Memory and Hippocampal Long-Term Potentiation in a Rat Model of Chronic Cerebral Hypoperfusion

“…The glutamatergic, GABAergic, cholinergic and monoaminergic neurotransmitters were observed to highly regulate the hippocampal activity, which play an imperative role in memory acquisition, consolidation and storage in the brain 40,41 . Kaundal, et al .…”

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

“…AD patients have complex neurochemical disturbances including of the catecholaminergic, cholinergic and glutaminergic neuronal systems [26]. AD patients have higher MAO-B activity than healthy controls, and this increased MAO-B activity may reflect abnormalities in the dopaminergic system [27].…”

Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting Various Pathological Events and Alteration in Neurotransmitter Levels in Rat’s Brain

“…Aβ in both clinical and preclinical AD, has reports to causes catecholaminergic deficit by escalating AChE enzymatic activity [44,45]. In agreement with the previous findings, the present study also showed significant increase in AChE activity in Aβ infused brains [6][7][8][9][10]. However, the treatment of lupeol was able to significantly decrease AChE activity as reported earlier [17].…”

Embelin Improves the Spatial Memory and Hippocampal Long-Term Potentiation in a Rat Model of Chronic Cerebral Hypoperfusion

“…The glutamatergic, GABAergic, cholinergic and monoaminergic neurotransmitters were observed to highly regulate the hippocampal activity, which play an imperative role in memory acquisition, consolidation and storage in the brain 40,41 . Kaundal, et al .…”

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

“…AD patients have complex neurochemical disturbances including of the catecholaminergic, cholinergic and glutaminergic neuronal systems [26]. AD patients have higher MAO-B activity than healthy controls, and this increased MAO-B activity may reflect abnormalities in the dopaminergic system [27].…”

Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting Various Pathological Events and Alteration in Neurotransmitter Levels in Rat’s Brain

“…Aβ in both clinical and preclinical AD, has reports to causes catecholaminergic deficit by escalating AChE enzymatic activity [44,45]. In agreement with the previous findings, the present study also showed significant increase in AChE activity in Aβ infused brains [6][7][8][9][10]. However, the treatment of lupeol was able to significantly decrease AChE activity as reported earlier [17].…”

Embelin Improves the Spatial Memory and Hippocampal Long-Term Potentiation in a Rat Model of Chronic Cerebral Hypoperfusion

“…The glutamatergic, GABAergic, cholinergic and monoaminergic neurotransmitters were observed to highly regulate the hippocampal activity, which play an imperative role in memory acquisition, consolidation and storage in the brain 40,41 . Kaundal, et al .…”

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

“…AD patients have complex neurochemical disturbances including of the catecholaminergic, cholinergic and glutaminergic neuronal systems [26]. AD patients have higher MAO-B activity than healthy controls, and this increased MAO-B activity may reflect abnormalities in the dopaminergic system [27].…”