Neurotoxicologic investigations of the pesticide dichlorvos (DDVP). Effects on the central and peripheral nervous system

Comparison of the effect of subacute organophosphate exposure on the cortical and peripheral evoked activity in rats

“…Increased latency of the somatosensory cortical evoked potential and slowed conduction velocity of the peripheral nerve, the two major effects of OPs observed in the present work, seem to be in line. Similar effects were observed in our previous works with partly different OPs (dimethoate, dichlorvos, methyl parathion) and dosing times (up to 12 weeks) [6,7,21]. Reduced conduction velocity may well have caused the delay of the cortical somatosensory response (but probably not of the visual one where no peripheral nerves are involved) and there are indications that exposure to OPs results in functional damage to peripheral nerves in humans [22,23] and animals [24].…”

Comparison of the effect of subacute organophosphate exposure on the cortical and peripheral evoked activity in rats

“…Increased latency of the somatosensory cortical evoked potential and slowed conduction velocity of the peripheral nerve, the two major effects of OPs observed in the present work, seem to be in line. Similar effects were observed in our previous works with partly different OPs (dimethoate, dichlorvos, methyl parathion) and dosing times (up to 12 weeks) [6,7,21]. Reduced conduction velocity may well have caused the delay of the cortical somatosensory response (but probably not of the visual one where no peripheral nerves are involved) and there are indications that exposure to OPs results in functional damage to peripheral nerves in humans [22,23] and animals [24].…”

Assessment of the cytotoxic and mutagenic potential of dichlorvos (DDVP) using in silico classification model; a health hazard awareness in Nigeria

“…For example, nausea, vomiting, lacrimation, salivation, bradycardia, and respiratory failure may cause death [ 60 ]. According to Illés and László, subchronic administration of DDVP (0.8 mg/kg daily for six weeks) significantly altered the function of CNS in CFY male rats [ 61 ].…”

A Perspective on Covalent Inhibitors: Research and Development Trends of Warheads and Targets

“…217 Rivastigmine (FDA 2000, Exelon®) 218 and metrifonate (BAY-A-9826, ProMem, 1997) 219,220 are classified as pseudo-irreversible inhibitors because they react with the critical active site serine residue to form a covalent carbamoyl-AChE complex that temporarily prevents the hydrolysis of acetylcholine in the active site 218 However, metrifonate was abandoned as a treatment for AD because it produces severe muscular and life-threatening respiratory paralysis in some AD patients, a sign of organophosphateinduced delayed neuropathy. 220,221 Irreversible AChR inhibitors are likely to have selectivity for central nervous system (CNS) because of the reduced rate of resynthesis of CNS AChE. The structural requirements for irreversible AChE inhibitors are thus relaxed; an AChE inhibitor must form an inhibitor-enzyme inactive complex that does not undergo spontaneous hydrolysis.…”

Comparison of the effect of subacute organophosphate exposure on the cortical and peripheral evoked activity in rats

“…Increased latency of the somatosensory cortical evoked potential and slowed conduction velocity of the peripheral nerve, the two major effects of OPs observed in the present work, seem to be in line. Similar effects were observed in our previous works with partly different OPs (dimethoate, dichlorvos, methyl parathion) and dosing times (up to 12 weeks) [6,7,21]. Reduced conduction velocity may well have caused the delay of the cortical somatosensory response (but probably not of the visual one where no peripheral nerves are involved) and there are indications that exposure to OPs results in functional damage to peripheral nerves in humans [22,23] and animals [24].…”

Assessment of the cytotoxic and mutagenic potential of dichlorvos (DDVP) using in silico classification model; a health hazard awareness in Nigeria

“…For example, nausea, vomiting, lacrimation, salivation, bradycardia, and respiratory failure may cause death [ 60 ]. According to Illés and László, subchronic administration of DDVP (0.8 mg/kg daily for six weeks) significantly altered the function of CNS in CFY male rats [ 61 ].…”

A Perspective on Covalent Inhibitors: Research and Development Trends of Warheads and Targets

“…217 Rivastigmine (FDA 2000, Exelon®) 218 and metrifonate (BAY-A-9826, ProMem, 1997) 219,220 are classified as pseudo-irreversible inhibitors because they react with the critical active site serine residue to form a covalent carbamoyl-AChE complex that temporarily prevents the hydrolysis of acetylcholine in the active site 218 However, metrifonate was abandoned as a treatment for AD because it produces severe muscular and life-threatening respiratory paralysis in some AD patients, a sign of organophosphateinduced delayed neuropathy. 220,221 Irreversible AChR inhibitors are likely to have selectivity for central nervous system (CNS) because of the reduced rate of resynthesis of CNS AChE. The structural requirements for irreversible AChE inhibitors are thus relaxed; an AChE inhibitor must form an inhibitor-enzyme inactive complex that does not undergo spontaneous hydrolysis.…”

Comparison of the effect of subacute organophosphate exposure on the cortical and peripheral evoked activity in rats

“…Increased latency of the somatosensory cortical evoked potential and slowed conduction velocity of the peripheral nerve, the two major effects of OPs observed in the present work, seem to be in line. Similar effects were observed in our previous works with partly different OPs (dimethoate, dichlorvos, methyl parathion) and dosing times (up to 12 weeks) [6,7,21]. Reduced conduction velocity may well have caused the delay of the cortical somatosensory response (but probably not of the visual one where no peripheral nerves are involved) and there are indications that exposure to OPs results in functional damage to peripheral nerves in humans [22,23] and animals [24].…”

Assessment of the cytotoxic and mutagenic potential of dichlorvos (DDVP) using in silico classification model; a health hazard awareness in Nigeria

“…For example, nausea, vomiting, lacrimation, salivation, bradycardia, and respiratory failure may cause death [ 60 ]. According to Illés and László, subchronic administration of DDVP (0.8 mg/kg daily for six weeks) significantly altered the function of CNS in CFY male rats [ 61 ].…”

A Perspective on Covalent Inhibitors: Research and Development Trends of Warheads and Targets

“…217 Rivastigmine (FDA 2000, Exelon®) 218 and metrifonate (BAY-A-9826, ProMem, 1997) 219,220 are classified as pseudo-irreversible inhibitors because they react with the critical active site serine residue to form a covalent carbamoyl-AChE complex that temporarily prevents the hydrolysis of acetylcholine in the active site 218 However, metrifonate was abandoned as a treatment for AD because it produces severe muscular and life-threatening respiratory paralysis in some AD patients, a sign of organophosphateinduced delayed neuropathy. 220,221 Irreversible AChR inhibitors are likely to have selectivity for central nervous system (CNS) because of the reduced rate of resynthesis of CNS AChE. The structural requirements for irreversible AChE inhibitors are thus relaxed; an AChE inhibitor must form an inhibitor-enzyme inactive complex that does not undergo spontaneous hydrolysis.…”