2007
DOI: 10.1080/10915810701582913 View full text |Buy / Rent full text
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Abstract: Neurotoxicity secondary to oil-soluble artemisinins has been reported in various animal species. The onset of neurotoxicity and toxicokinetics of oral artelinic acid (AL), a water-soluble artemisinin, were investigated. After dose range study, rats were dosed at either 160 mg/kg daily for 9 consecutive days or at 288 mg/kg once every other day for five doses, so that the total dose (1440 mg/kg) and duration (9 days) were identical. Neuronal damage of varying severity was identified beginning as early as 1 day … Show more

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“…Similar anorectic toxicity was also reported in animals treated with AM, AE and DHA (Li et al, 1998a). It is postulated that this decrease in GI motility could result from a decrease in vagal tone as a consequence of a decline in sympathetic outflow (Hull & Maher 1990;Si et al, 2007).…”
Section: Cause Of Al Accumulation After Intragastric Administrationmentioning
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“…Similar anorectic toxicity was also reported in animals treated with AM, AE and DHA (Li et al, 1998a). It is postulated that this decrease in GI motility could result from a decrease in vagal tone as a consequence of a decline in sympathetic outflow (Hull & Maher 1990;Si et al, 2007).…”
Section: Cause Of Al Accumulation After Intragastric Administrationmentioning
“…Furthermore, progressive delays in gastric emptying and drug accretion were only found in rats treated with oral AL at 160 mg/kg. These results imply that the observations of delayed gastric emptying in turn results in AL accumulation, and the mean half-life of AL was correspondingly extended on the last dosing day compared to day 1 (Si et al, 2007).…”
Section: Cause Of Al Accumulation After Intragastric Administrationmentioning
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