Neurotensin pathway in digestive cancers and clinical applications: an overview

Christou, Niki; Blondy, Sabrina; David, Valentin; Verdier, Mireille; Lalloué, Fabrice; Jauberteau, Marie‐Odile; Mathonnet, Muriel; Perraud, Aurélie

doi:10.1038/s41419-020-03245-8

Cited by 31 publications

(31 citation statements)

References 104 publications

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“…Studies in mice showed that hepatic sortilin overexpression reduced the production of Apolipoprotein B (ApoB) [37]; Mechanistically, Amengual et al found that autophagy is required for SORT1-mediated degradation of ApoB [38]. In addition, sortilin recently emerged as a promising tumor target as its expression was found to be increased in several types of cancers including digestive cancers [39][40][41], but its expression and impact in GC is unclear. Autophagy is a highly conserved intracellular homeostasis mechanism through which cellular material is delivered to lysosomes for degradation, resulting in the basal turnover of cell components and providing energy and macromolecular precursors.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

et al. 2021

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Increasing studies have found that circular RNAs (circRNAs) are aberrantly expressed and play important roles in the occurrence and development of human cancers. However, the function of circRNAs on environmental carcinogen-induced gastric cancer (GC) progression remains poorly elucidated. In the present study, hsa_circ_0110389 was identified as a novel upregulated circRNA in malignant-transformed GC cells through RNA-seq, and subsequent quantitative real-time PCR verified that hsa_circ_0110389 was significantly increased in GC tissues and cells. High hsa_circ_0110389 expression associates with advanced stages of GC and predicts poor prognosis. Knockdown and overexpression assays demonstrated that hsa_circ_0110389 regulates proliferation, migration, and invasion of GC cells in vitro. In addition, hsa_circ_0110389 was identified to sponge both miR-127-5p and miR-136-5p and SORT1 was validated as a direct target of miR-127-5p and miR-136-5p through multiple mechanism assays; moreover, hsa_circ_0110389 sponged miR-127-5p/miR-136-5p to upregulate SORT1 expression and hsa_circ_0110389 promoted GC progression through the miR-127-5p/miR-136-5p–SORT1 pathway. Finally, hsa_circ_0110389 knockdown suppressed GC growth in vivo. Taken together, our findings firstly identify the role of hsa_circ_0110389 in GC progression, which is through miR-127-5p/miR-136-5p–SORT1 pathway, and our study provides novel insight for the identification of diagnostic/prognostic biomarkers and therapeutic targets for GC.

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Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

et al. 2021

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“…Recent studies have revealed that neuropeptides in a variety of tumor systems may be regulated by exosomes and that abnormalities in such regulation can affect neuroendocrine function [ 15 – 17 ]. Exosomes are membrane-bound vesicles that can transport biologically active molecules between cells [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Exosomal lncRNA AC007099.1 Regulates the Expression of Neuropeptide-Related FAP, as a Potential Biomarker for Hepatocarcinogenesis

Li¹,

Xiao²,

Guo-lian³

et al. 2022

Disease Markers

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Neuropeptide-associated fibroblast activation protein (FAP) may be an important risk factor for neurovascular metastasis in hepatocellular carcinoma. Analysis of The Cancer Genome Atlas (TCGA) database showed that FAP mRNA was highly expressed in most human tumor tissues. The HPA database then verified that FAP was highly expressed in tumor tissues following protein translation. Survival analysis then showed that the level of FAP expression significantly affected the overall survival (OS), progress free interval (PFI), and disease specific survival (DSS) of patients with hepatocellular carcinoma. A high expression of FAP in tumor tissue is associated with poor patient prognosis. According to the results of spearman correlation, AC009099 and FAP were negatively correlated with miR-7152 expression, while AC009099 and FAP expression were positively correlated. The lncRNA AC007099.1, which may serve as a potential target for the treatment of hepatocellular carcinoma, was associated with liver cancer. AC007099.1/miR-7152/FAP was found to be associated with immune infiltration in patients with hepatocellular carcinoma. Enrichment analysis suggests that the AC009099/miR-7152/FAP ceRNA regulatory network is associated with neuropeptide functional pathways. In conclusion, a neuropeptide-related AC009099/miR-7152/FAP ceRNA regulatory network was constructed in this study.

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“…Patients with solid tumours that originate from these organs tend to have higher morbidity and mortality compared with other organ systems (7). Previous studies have shown that there are common intersections between tumorigenesis mechanisms and regulatory networks in different digestive cancers (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Expression Signature of the AT-Rich Interactive Domain Gene Family Identified in Digestive Cancer

Liu

Wang

et al. 2022

Front. Med.

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BackgroundThe AT-rich interactive domain (ARID) gene family of 15 proteins has an important role in development and proliferation. Gene expression alterations of the ARID family are correlated with the pathogenesis of digestive cancer, but systematic research has not been conducted.MethodsWe obtained transcriptome sequencing data, clinical characteristics and stemness indices of the seven main types of digestive cancer (cholangiocarcinoma, colon adenocarcinoma, oesophageal carcinoma, liver hepatocellular carcinoma, pancreatic adenocarcinoma, rectum adenocarcinoma and stomach adenocarcinoma) from public pan-cancer data to combine the analysis of the expression and prognostic signature of the ARID gene family. The stromal and immune scores for each sample were calculated to explore the correlations between the ARID gene family members and the tumour microenvironment.ResultsAfter screening, 1,920 digestive cancer samples were included in our study. ARID3C was expressed at low levels throughout the digestive cancer samples. The expression levels of ARID1A and JARID1C were relatively high, but there was striking heterogeneity across the different cancer types for specific family members. The survival analysis indicated that many genes were significantly related to the prognosis of patients with liver hepatocellular carcinoma. The stemness indices, stromal score, and immune score analysis showed that the expression of a single ARID gene had characteristic consistency in each tumour, but the levels among the different genes still varied.ConclusionOur systematic study of the ARID gene family and its association with the immune infiltrate, tumour microenvironment and outcomes of digestive cancer patients focus on the complex relations and indicate the need to study each ARID member as an individual in a specific cancer type.

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Neurotensin pathway in digestive cancers and clinical applications: an overview

Cited by 31 publications

References 104 publications

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Serum Exosomal lncRNA AC007099.1 Regulates the Expression of Neuropeptide-Related FAP, as a Potential Biomarker for Hepatocarcinogenesis

Expression Signature of the AT-Rich Interactive Domain Gene Family Identified in Digestive Cancer

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