2001
DOI: 10.1530/eje.0.1450669
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Abstract: This review summarizes the current knowledge of the biosynthesis of neurosteroids in the human brain, the enzymes mediating these reactions, their localization and the putative effects of neurosteroids. Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in human brain. The functions att… Show more

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Cited by 417 publications
(170 citation statements)
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References 121 publications
(120 reference statements)
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“…glioma cell lines express aromatase and, are, therefore, capable of producing oestrogens from androgens (Stoffel-Wagner, 2001;Yague et al, 2004). The present study demonstrates that melatonin, at 1 mM concentration, reduces the synthesis of oestrogens in C6 glioma cells, through the inhibition of aromatase, the enzyme that catalyses the rate-limiting step in the conversion of androgens into oestrogens (Zhou et al, 1993).…”
Section: Discussionsupporting
confidence: 50%
See 1 more Smart Citation
“…glioma cell lines express aromatase and, are, therefore, capable of producing oestrogens from androgens (Stoffel-Wagner, 2001;Yague et al, 2004). The present study demonstrates that melatonin, at 1 mM concentration, reduces the synthesis of oestrogens in C6 glioma cells, through the inhibition of aromatase, the enzyme that catalyses the rate-limiting step in the conversion of androgens into oestrogens (Zhou et al, 1993).…”
Section: Discussionsupporting
confidence: 50%
“…Steroids or their precursors can be metabolised in the CNS to derivates which can affect brain function and may have an important clinical significance (Weidenfeld and Schiller, 1984). Previous studies have shown that human brain and human neuronal cell lines secrete oestrogens (Stoffel-Wagner, 2001, 2003.…”
Section: Discussionmentioning
confidence: 99%
“…20 The interaction between steroids and neurotransmitters in the CNS is still an area of active investigation. 21 Steroid hormones easily cross the blood-brain barrier, where extensive steroid metabolism occurs. Neurosteroids, whether originating from outside the CNS or synthesized de novo in the brain, modulate a wide range of neurotransmitters in the brain, including GABA (g-aminobutyric acid), NMDA (N-methyl-d-aspartate), and nicotinic, muscarinic, serotonin (5-HT 3 ), kainate, glycine and sigma receptors.…”
Section: Neurobiology Of Sexual Responsementioning
confidence: 99%
“…Overall, it is still possible that the endocrine findings are not related to a diagnostic specificity, and the elevated cortisol/DHEA(S) ratios in schizophrenia patients may be associated with impaired stress-response (Wolf and Kirschbaum, 1999;Boudarene and Legros, 2002;Kimonides et al, 1999) and may lead to dysregulated neurotransmission (Akwa and Baulieu, 2000), resulting in chronic and progressive deterioration in cognitive, emotional, and psychosocial functions (Wen et al, 2001;Johnson et al, 2002). Indeed, clinical investigations produced evidence of the involvement of neuroactive steroids in conditions such as fatigue during pregnancy, premenstrual syndrome, postpartum depression, epilepsy, dementia, depressive, and anxiety disorders (Stoffel-Wagner, 2001;Pisua and Serra, 2004).…”
Section: Commentmentioning
confidence: 99%